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- W1992022603 abstract "We report the effect of calcitriol on natural killer (NK) cell activity in patients with chronic renal failure undergoing long-term hemodialysis. Natural killer cytotoxicity was significantly decreased in these patients when compared to healthy control subjects (13.1 ± 1.3 vs 38.8 ± 2.4%, P < 0.001). These patients also have decreased levels of calcitriol (17 ± 3 vs 36 ± 3 pg/ml, P < 0.001). After 14 days of oral treatment with calcitriol at a dose of 0.5 μg per day, a significant increase in NK activity was observed (20.2 ± 1.6%, P < 0.001). This increase was maintained after 28 days of treatment (21.1 ± 2%, P < 0.001). These results suggest that the decreased serum calcitriol might contribute to the diminished NK activity found in hemodialyzed patients, and suggests a new potential therapeutical utility of calcitriol as modulator of the immune function in these patients." @default.
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- W1992022603 date "1989-01-01" @default.
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- W1992022603 title "The effect of calcitriol on natural killer cell activity in hemodialyzed patients" @default.
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- W1992022603 doi "https://doi.org/10.1016/0022-4731(89)90120-9" @default.
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