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• W1992023133 endingPage "1903" @default.
• W1992023133 startingPage "1896" @default.
• W1992023133 abstract "The skeletal muscle sodium channel mutant I1160V cosegregates with a disease phenotype producing myotonic discharges (observed as muscle stiffness) that are worsened by elevated K+ levels but unaffected by cooling. The I1160V alpha-subunit was co-expressed with the beta1-subunit in Xenopus oocytes. An electrophysiological characterization was undertaken to examine the underlying biophysical characteristics imposed by this mutation. Two abnormalities were found. 1) The voltage dependence of steady-state fast inactivation was reduced in I1160V, which resulted in faster rates of closed-state fast inactivation onset and recovery in I1160V compared with wild-type channels. 2) The rates of deactivation were slower in I1160V than in wild-type channels. Using a computer-simulated model, the combination of both defects elicited myotonic runs under conditions of elevated K+, consistent with the observed phenotype of the mutant." @default.
• W1992023133 created "2016-06-24" @default.
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• W1992023133 date "1997-10-01" @default.
• W1992023133 modified "2023-10-15" @default.
• W1992023133 title "Defective fast inactivation recovery and deactivation account for sodium channel myotonia in the I1160V mutant" @default.
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• W1992023133 doi "https://doi.org/10.1016/s0006-3495(97)78220-1" @default.
• W1992023133 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1181090" @default.
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