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- W1992024354 abstract "In this Letter, we describe an easy and straightforward strategy for the preparation of acyloins (α-hydroxyketones) from Morita–Baylis–Hillman adducts, based on a Curtius rearrangement. Different acyloins were obtained with good overall yield (>40% for three steps). To exemplify the synthetic usefulness of this strategy, total synthesis of (±)-bupropion, a dopamine, and nor-epinefrine reuptake inhibitor has been accomplished in eight steps with an overall yield of 25%." @default.
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- W1992024354 date "2008-06-01" @default.
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- W1992024354 title "Acyloins from Morita–Baylis–Hillman adducts: an alternative approach to the racemic total synthesis of bupropion" @default.
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- W1992024354 doi "https://doi.org/10.1016/j.tetlet.2008.04.040" @default.
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