Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992026462> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1992026462 endingPage "355" @default.
- W1992026462 startingPage "351" @default.
- W1992026462 abstract "The cytokine, IFN-gamma, has been shown in vitro to inhibit bone resorption, but the mechanisms responsible for this inhibition have not been clearly defined. Cathepsin K is a major protease responsible for bone resorption. IFN-gamma may inhibit bone resorption through down-regulation of osteoclast genes, including cathepsin K. To test the hypothesis, we investigated the effect of IFN-gamma on cathepsin K expression in the MOCP-5 and wild-type mouse bone marrow co-culture systems by Northern blot as well as osteoclast formation at different stages of differentiation. The results show that IFN-gamma down-regulates mRNA levels of cathepsin K in a time- and dose-dependent manner. Consequently, cathepsin K protein production is also reduced by IFN-gamma. Moreover, our results indicate that IFN-gamma inhibits osteoclast formation only early in osteoclast differentiation. IL-6 and TNFalpha did not significantly affect cathepsin K gene expression in osteoclasts. However, IL-1alpha stimulated gene expression. In conclusion, our data suggest that the actions of IFN-gamma on osteoclastic bone resorption may be mediated by its effects on both osteoclast formation at an early stage and osteoclast gene expression in mature osteoclasts." @default.
- W1992026462 created "2016-06-24" @default.
- W1992026462 creator A5008889928 @default.
- W1992026462 creator A5045408082 @default.
- W1992026462 creator A5089134735 @default.
- W1992026462 date "2001-01-01" @default.
- W1992026462 modified "2023-09-23" @default.
- W1992026462 title "Interferon-γ Down-regulates Gene Expression of Cathepsin K in Osteoclasts and Inhibits Osteoclast Formation" @default.
- W1992026462 cites W1515227258 @default.
- W1992026462 cites W1966897576 @default.
- W1992026462 cites W1969481354 @default.
- W1992026462 cites W1982093100 @default.
- W1992026462 cites W1986536728 @default.
- W1992026462 cites W2025062557 @default.
- W1992026462 cites W2038114059 @default.
- W1992026462 cites W2043556633 @default.
- W1992026462 cites W2050596361 @default.
- W1992026462 cites W2058616210 @default.
- W1992026462 cites W2060803891 @default.
- W1992026462 cites W2120837429 @default.
- W1992026462 cites W2140039015 @default.
- W1992026462 cites W4244711351 @default.
- W1992026462 cites W4294216491 @default.
- W1992026462 doi "https://doi.org/10.1177/00220345010800011001" @default.
- W1992026462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11269728" @default.
- W1992026462 hasPublicationYear "2001" @default.
- W1992026462 type Work @default.
- W1992026462 sameAs 1992026462 @default.
- W1992026462 citedByCount "54" @default.
- W1992026462 countsByYear W19920264622012 @default.
- W1992026462 countsByYear W19920264622013 @default.
- W1992026462 countsByYear W19920264622014 @default.
- W1992026462 countsByYear W19920264622015 @default.
- W1992026462 countsByYear W19920264622016 @default.
- W1992026462 countsByYear W19920264622017 @default.
- W1992026462 countsByYear W19920264622020 @default.
- W1992026462 countsByYear W19920264622021 @default.
- W1992026462 countsByYear W19920264622022 @default.
- W1992026462 crossrefType "journal-article" @default.
- W1992026462 hasAuthorship W1992026462A5008889928 @default.
- W1992026462 hasAuthorship W1992026462A5045408082 @default.
- W1992026462 hasAuthorship W1992026462A5089134735 @default.
- W1992026462 hasConcept C101990758 @default.
- W1992026462 hasConcept C134018914 @default.
- W1992026462 hasConcept C146562846 @default.
- W1992026462 hasConcept C153911025 @default.
- W1992026462 hasConcept C167844969 @default.
- W1992026462 hasConcept C181199279 @default.
- W1992026462 hasConcept C185592680 @default.
- W1992026462 hasConcept C202751555 @default.
- W1992026462 hasConcept C2776033226 @default.
- W1992026462 hasConcept C55493867 @default.
- W1992026462 hasConcept C673006 @default.
- W1992026462 hasConcept C86803240 @default.
- W1992026462 hasConcept C95444343 @default.
- W1992026462 hasConceptScore W1992026462C101990758 @default.
- W1992026462 hasConceptScore W1992026462C134018914 @default.
- W1992026462 hasConceptScore W1992026462C146562846 @default.
- W1992026462 hasConceptScore W1992026462C153911025 @default.
- W1992026462 hasConceptScore W1992026462C167844969 @default.
- W1992026462 hasConceptScore W1992026462C181199279 @default.
- W1992026462 hasConceptScore W1992026462C185592680 @default.
- W1992026462 hasConceptScore W1992026462C202751555 @default.
- W1992026462 hasConceptScore W1992026462C2776033226 @default.
- W1992026462 hasConceptScore W1992026462C55493867 @default.
- W1992026462 hasConceptScore W1992026462C673006 @default.
- W1992026462 hasConceptScore W1992026462C86803240 @default.
- W1992026462 hasConceptScore W1992026462C95444343 @default.
- W1992026462 hasIssue "1" @default.
- W1992026462 hasLocation W19920264621 @default.
- W1992026462 hasLocation W19920264622 @default.
- W1992026462 hasOpenAccess W1992026462 @default.
- W1992026462 hasPrimaryLocation W19920264621 @default.
- W1992026462 hasRelatedWork W1979481227 @default.
- W1992026462 hasRelatedWork W2020087564 @default.
- W1992026462 hasRelatedWork W2070222842 @default.
- W1992026462 hasRelatedWork W2088132708 @default.
- W1992026462 hasRelatedWork W2126910264 @default.
- W1992026462 hasRelatedWork W2132517007 @default.
- W1992026462 hasRelatedWork W2345282274 @default.
- W1992026462 hasRelatedWork W2403179950 @default.
- W1992026462 hasRelatedWork W4309452523 @default.
- W1992026462 hasRelatedWork W4318020048 @default.
- W1992026462 hasVolume "80" @default.
- W1992026462 isParatext "false" @default.
- W1992026462 isRetracted "false" @default.
- W1992026462 magId "1992026462" @default.
- W1992026462 workType "article" @default.