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- W1992034127 abstract "A comparative evaluation of serum and secretory antibody responses to influenza A2/HK, para-influenza and other viruses was undertaken in groups of children with acute viral pharyngitis, croup or bronchiolitis. The techniques of tissue culture infectivity, neutralizing antibody assay, and indirect immunofluorescence were employed to recover infectious virus from the respiratory tract and to characterize specific antibody response in the serum and nasopharynx. Serologic evidence of infection or recovery of influenza A2/HK or parainfluenza 1 and 3 viruses was most frequently observed in patients with croup. The sequence of appearance and the levels of serum γG, γA and γM influenza and para-influenza antibodies in patients with pharyngitis, croup or bronchiolitis were generally similar. However, nasopharyngeal antibody levels to influenza or para-influenza viruses were significantly lower in patients with croup when compared to the levels obtained in patients with pharyngitis or bronchiolitis. Furthermore, nasopharyngeal antibody response to influenza virus was conspicuously absent in a few patients with severe influenza A2/HK croup who required tracheostomy on hospitalization. The reduction or absence of nasopharyngeal antibody levels was not related to virus-antibody complexes and no change was observed in nasopharyngeal antibody levels for as long as 3-4 months after recovery from the infection. These observations suggest that alterations of secretory immune response in the respiratory tract may be related to the pathogenesis of viral croup." @default.
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- W1992034127 date "1974-04-01" @default.
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- W1992034127 title "IMMUNOLOGIC ASPECTS OF VIRAL CROUP IN CHILDHOOD" @default.
- W1992034127 doi "https://doi.org/10.1203/00006450-197404000-00457" @default.
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