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- W1992034805 abstract "A study was made of the effects of a polyphenolic antihypoxic agent on respiration in isolated mitochondria and homogenates of skeletal muscles and on the bioenergetic functions and performance capacity of runners. Polarographic analysis showed that preincubation of mitochondria isolated from skeletal muscles with the antihypoxic agent inhibited glutamate oxidation more than twofold in state 4. In homogenates of skeletal muscles, the antihypoxic agent in the presence or absence of an uncoupler strongly inhibited or slightly stimulated glutamate oxidation in the initial mitochondrial state, respectively. Thus, the antihypoxic agent inhibited mitochondrial ATPase but did not change the ATP synthase activity or exert a direct effect on the respiratory chain. The antihypoxic agent administered to runners at a concentration of about 30 mg/kg body mass 1 h prior to exercise at maximum power with a maximum duration of 1–10 min allowed higher acidification but did not affect the major bioenergetic functions such as O2 consumption, excess CO2 production, O2 debt, and O2 demand. The agent substantially increased the performance capacity of runners during exercise with a maximum duration of 3–10 min. Under competition conditions, administration of the agent to runners improved the results by 2–6% in 200- to 10 000-m races." @default.
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- W1992034805 date "2004-03-01" @default.
- W1992034805 modified "2023-10-14" @default.
- W1992034805 title "Changes in Bioenergetic Functions and Performance Capacity of Athletes after Administration of a Polyphenolic Antihypoxic Agent" @default.
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- W1992034805 doi "https://doi.org/10.1023/b:hump.0000021651.15516.73" @default.
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