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- W1992035582 abstract "Melanin is produced in melanocytes and stored in melanosomes. In spite of its beneficial sun-protective effect, abnormal accumulation of melanin results in esthetic problems. Hydroquinone, competing with tyrosine, is a major ingredient in topical pharmacological agents. However, frequent adverse reactions are amongst its major limitation. To solve this problem, several alternatives such as arbutin, kojic acid, aloesin, and 4-n-butyl resorcinol have been developed. Herein, we classify hypopigmenting agents according to their mechanism of action; a) regulation of enzyme, which is subdivided into three categories, i) regulation of transcription and maturation of tyrosinase, ii) inhibition of tyrosinase activity, and iii) post-transcriptional control of tyrosinase; b) inhibition of melanosome transfer, and c) additional mechanisms such as regulation of the melanocyte environment and antioxidant agents." @default.
- W1992035582 created "2016-06-24" @default.
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- W1992035582 date "2012-01-01" @default.
- W1992035582 modified "2023-10-17" @default.
- W1992035582 title "Topical Hypopigmenting Agents for Pigmentary Disorders and Their Mechanisms of Action" @default.
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- W1992035582 doi "https://doi.org/10.5021/ad.2012.24.1.1" @default.
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