Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992035659> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W1992035659 endingPage "106" @default.
- W1992035659 startingPage "101" @default.
- W1992035659 abstract "Phosphocholine (PC)-specific antibodies that arise in the mouse in response to Proteus morganii (PM) and use V1-DFL16.1-JH1 are characterized by a number of recurring mutations. Most striking is an invariant A for G substitution in codon 95 of VH which results in an asparagine instead of aspartate at that position. Because of the apparent importance of this substitution in an anti-PC(PM) response, we wanted to determine the molecular basis for this base change. A cDNA library derived from pre-immune splenic B cells was examined for the frequency of VDJ containing the A substitution at 95 and the presence of additional point mutations in these sequences. Six different cDNA were isolated which contained an A substitution at the VD junction (frequency 0.00009); a seventh positive cDNA could not be examined. The V segments of four of these cDNA matched known germline genes and were, therefore, unmutated. Two others closely matched V in families whose members have not all been characterized, hence, it is not known whether the mutations observed are somatic or germline in origin. Sequences of 35 cDNA clones, containing the same V segment but differing in D, J and junctional nucleotides, revealed no mutations. These results indicate that the A substitution generated at codon 95 is most likely a product of V-DJ joining." @default.
- W1992035659 created "2016-06-24" @default.
- W1992035659 creator A5023105132 @default.
- W1992035659 creator A5059291353 @default.
- W1992035659 creator A5064466516 @default.
- W1992035659 date "1982-02-01" @default.
- W1992035659 modified "2023-09-27" @default.
- W1992035659 title "Stability of the DNA apyrimidinic site" @default.
- W1992035659 cites W135588916 @default.
- W1992035659 cites W1377731 @default.
- W1992035659 cites W1496246291 @default.
- W1992035659 cites W1593086337 @default.
- W1992035659 cites W1606857291 @default.
- W1992035659 cites W1963670089 @default.
- W1992035659 cites W2023375580 @default.
- W1992035659 cites W2063894827 @default.
- W1992035659 cites W2077008254 @default.
- W1992035659 cites W2084695608 @default.
- W1992035659 doi "https://doi.org/10.1016/0165-7992(82)90012-4" @default.
- W1992035659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6799805" @default.
- W1992035659 hasPublicationYear "1982" @default.
- W1992035659 type Work @default.
- W1992035659 sameAs 1992035659 @default.
- W1992035659 citedByCount "11" @default.
- W1992035659 crossrefType "journal-article" @default.
- W1992035659 hasAuthorship W1992035659A5023105132 @default.
- W1992035659 hasAuthorship W1992035659A5059291353 @default.
- W1992035659 hasAuthorship W1992035659A5064466516 @default.
- W1992035659 hasConcept C104317684 @default.
- W1992035659 hasConcept C109825262 @default.
- W1992035659 hasConcept C13514818 @default.
- W1992035659 hasConcept C153911025 @default.
- W1992035659 hasConcept C176944494 @default.
- W1992035659 hasConcept C187882448 @default.
- W1992035659 hasConcept C501734568 @default.
- W1992035659 hasConcept C54355233 @default.
- W1992035659 hasConcept C552990157 @default.
- W1992035659 hasConcept C86803240 @default.
- W1992035659 hasConceptScore W1992035659C104317684 @default.
- W1992035659 hasConceptScore W1992035659C109825262 @default.
- W1992035659 hasConceptScore W1992035659C13514818 @default.
- W1992035659 hasConceptScore W1992035659C153911025 @default.
- W1992035659 hasConceptScore W1992035659C176944494 @default.
- W1992035659 hasConceptScore W1992035659C187882448 @default.
- W1992035659 hasConceptScore W1992035659C501734568 @default.
- W1992035659 hasConceptScore W1992035659C54355233 @default.
- W1992035659 hasConceptScore W1992035659C552990157 @default.
- W1992035659 hasConceptScore W1992035659C86803240 @default.
- W1992035659 hasIssue "2" @default.
- W1992035659 hasLocation W19920356591 @default.
- W1992035659 hasLocation W19920356592 @default.
- W1992035659 hasOpenAccess W1992035659 @default.
- W1992035659 hasPrimaryLocation W19920356591 @default.
- W1992035659 hasRelatedWork W1489089338 @default.
- W1992035659 hasRelatedWork W1965881002 @default.
- W1992035659 hasRelatedWork W1990255234 @default.
- W1992035659 hasRelatedWork W1993062754 @default.
- W1992035659 hasRelatedWork W2010720786 @default.
- W1992035659 hasRelatedWork W2036729517 @default.
- W1992035659 hasRelatedWork W2098325466 @default.
- W1992035659 hasRelatedWork W2201808132 @default.
- W1992035659 hasRelatedWork W2409614280 @default.
- W1992035659 hasRelatedWork W4232569475 @default.
- W1992035659 hasVolume "103" @default.
- W1992035659 isParatext "false" @default.
- W1992035659 isRetracted "false" @default.
- W1992035659 magId "1992035659" @default.
- W1992035659 workType "article" @default.