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- W1992037783 abstract "To review the evidence from randomized controlled trials (RCTs) on the safety and efficacy of guanfacine in pediatric attention deficit hyperactivity disorder (ADHD), a bibliographic search up to May 2014 was performed using the Cochrane Library׳s Central Register of Controlled Trials, the Embase, PsycINFO, and Medline databases, and clinical trials registers. The search terms used were: [guanfacine] and [child or adolescent or pediatrics] and [randomized controlled trial] and [Attention Deficit Disorder with Hyperactivity or Attention Deficit Disorder or Attention Hyperactivity Disorder or Hyperactivity or ADHD]. A meta-analysis was performed using response, defined as a score ≤ 2 on the Clinical Global Impression Improvement score, as the outcome measure. In all, 7 out of 48 studies were included, for a total of 1752 participants. All studies compared guanfacine versus placebo, with a duration ranging from 6 to 16 weeks. In all, the Clinical Global Impression Improvement score was reported as a secondary measure. Overall, 694/1177 (59.0%) participants in the guanfacine group benefited from the treatment compared to 192/575 (33.3%) in the placebo group (pooled OR 3.2; 95%CI 2.4-4.1). The participants with at least one adverse event were 948 (82.4%) in the guanfacine and 376 (67.9%) in the placebo group (OR 2.6; 95%CI 1.6-4.4). Somnolence (OR 4.9), sedation (OR 2.8), and fatigue (OR 2.2), were the adverse events with the greatest risk of occurrence in the guanfacine versus the placebo group. On the basis of seven randomized, placebo controlled trials guanfacine resulted safe and effective in treating children and adolescents with ADHD." @default.
- W1992037783 created "2016-06-24" @default.
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- W1992037783 date "2014-10-01" @default.
- W1992037783 modified "2023-09-26" @default.
- W1992037783 title "Guanfacine for attention deficit and hyperactivity disorder in pediatrics: A systematic review and meta-analysis" @default.
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- W1992037783 doi "https://doi.org/10.1016/j.euroneuro.2014.08.001" @default.
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