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- W1992040805 abstract "The World Health Organization has predicted that by 2040 neurodegenerative diseases will overtake cancer to become the world’s second leading cause of death after cardiovascular disease. This has sparked the development of several European and American brain research initiatives focusing on elucidating the underlying cellular and molecular mechanisms of neurodegenerative diseases. Connexin (Cx) and pannexin (Panx) membrane channel proteins are conduits through which neuronal, glial, and vascular tissues interact. In the brain, this interaction is highly critical for homeostasis and brain repair after injury. Understanding the molecular mechanisms by which these membrane channels function, in health and disease, might be particularly influential in establishing conceptual frameworks to develop new therapeutics against Cx and Panx channels. This review focuses on current insights and emerging concepts, particularly the impact of connexin43 and pannexin1, under neuroprotective and neurodegenerative conditions within the context of astrocytes." @default.
- W1992040805 created "2016-06-24" @default.
- W1992040805 creator A5060119478 @default.
- W1992040805 creator A5071419705 @default.
- W1992040805 date "2016-05-01" @default.
- W1992040805 modified "2023-09-25" @default.
- W1992040805 title "Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1" @default.
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