FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992043883> ?p ?o ?g. }

• W1992043883 endingPage "57" @default.
• W1992043883 startingPage "51" @default.
• W1992043883 abstract "The method of anticodon loop replacement has been used to make derivatives of yeast tRNAPhe with the substitution at position 37 (tRNAGAAAPhe) and at the anticodon(tRNAGCAGPhe). A quantitative study of the interaction of various types of deacylated yeast tRNAPhe (tRNA+YPhe, tRNAGAAAPhe, tRNA−yPhe) with the P site of the [70S ribosome∗poly(U)]-complex was carried out at different Mg2+ concentrations and temperatures. The presence and nature of the nucleotide situated at the 3′-end of the anticodon are essential for such interaction in E coli ribosomes. Replacement of thee Y base with the unmodified adenosine decreases the interation enthalpy from 39 kcal/mol to 24 kcal/mol, whereas its removal reduces the interaction enthalpy to 16 kcal/mol. Replacement of the second anticodon nucleotide, adenosine, with cytosine further reduces the enthalphy to 6 kcal/mol, which is typical of tRNA-P site interaction in the absence of poly(U). In the absence of poly(U) the affinity of tRNA−YPhe for the P site of the 70S ribosome is five times lower than the affinity of tRNA+YPhe or tRNAGCAGPhe. Thus, in the ribosome the modified nucleotide stabilizes the codon-anticodon interaction through its stacking interaction with the codon-anticodon base stack. In addition, this decreases the free energy of binding as a result of the interaction of the modified nucleotide itself with the hydrophobic center of the P site." @default.
• W1992043883 created "2016-06-24" @default.
• W1992043883 creator A5018645514 @default.
• W1992043883 creator A5020479922 @default.
• W1992043883 creator A5049225414 @default.
• W1992043883 creator A5051388653 @default.
• W1992043883 creator A5075611268 @default.
• W1992043883 creator A5088650584 @default.
• W1992043883 date "1994-01-01" @default.
• W1992043883 modified "2023-09-30" @default.
• W1992043883 title "Effect of the nucleotide-37 on the interaction of tRNAPhe with the P site of Escherichia coli ribosomes" @default.
• W1992043883 cites W1494417233 @default.
• W1992043883 cites W1518064492 @default.
• W1992043883 cites W1564536968 @default.
• W1992043883 cites W1579537489 @default.
• W1992043883 cites W1605039020 @default.
• W1992043883 cites W1606553664 @default.
• W1992043883 cites W176521568 @default.
• W1992043883 cites W1965437363 @default.
• W1992043883 cites W1970667469 @default.
• W1992043883 cites W1973069142 @default.
• W1992043883 cites W1975107163 @default.
• W1992043883 cites W1976318017 @default.
• W1992043883 cites W1976497970 @default.
• W1992043883 cites W1979911160 @default.
• W1992043883 cites W1984090964 @default.
• W1992043883 cites W1991480269 @default.
• W1992043883 cites W1996060070 @default.
• W1992043883 cites W1997763889 @default.
• W1992043883 cites W2004247778 @default.
• W1992043883 cites W2012158738 @default.
• W1992043883 cites W2019208468 @default.
• W1992043883 cites W2028684255 @default.
• W1992043883 cites W2043708022 @default.
• W1992043883 cites W2049193281 @default.
• W1992043883 cites W2050952012 @default.
• W1992043883 cites W2052432617 @default.
• W1992043883 cites W2074365418 @default.
• W1992043883 cites W2078412971 @default.
• W1992043883 cites W2080261671 @default.
• W1992043883 cites W2088191152 @default.
• W1992043883 cites W2132513183 @default.
• W1992043883 cites W2409365140 @default.
• W1992043883 cites W2418469048 @default.
• W1992043883 cites W791884364 @default.
• W1992043883 doi "https://doi.org/10.1016/0300-9084(94)90062-0" @default.
• W1992043883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7518255" @default.
• W1992043883 hasPublicationYear "1994" @default.
• W1992043883 type Work @default.
• W1992043883 sameAs 1992043883 @default.
• W1992043883 citedByCount "8" @default.
• W1992043883 countsByYear W19920438832013 @default.
• W1992043883 countsByYear W19920438832019 @default.
• W1992043883 countsByYear W19920438832020 @default.
• W1992043883 crossrefType "journal-article" @default.
• W1992043883 hasAuthorship W1992043883A5018645514 @default.
• W1992043883 hasAuthorship W1992043883A5020479922 @default.
• W1992043883 hasAuthorship W1992043883A5049225414 @default.
• W1992043883 hasAuthorship W1992043883A5051388653 @default.
• W1992043883 hasAuthorship W1992043883A5075611268 @default.
• W1992043883 hasAuthorship W1992043883A5088650584 @default.
• W1992043883 hasConcept C104317684 @default.
• W1992043883 hasConcept C106774688 @default.
• W1992043883 hasConcept C153957851 @default.
• W1992043883 hasConcept C185581394 @default.
• W1992043883 hasConcept C185592680 @default.
• W1992043883 hasConcept C2776023528 @default.
• W1992043883 hasConcept C512185932 @default.
• W1992043883 hasConcept C547475151 @default.
• W1992043883 hasConcept C552990157 @default.
• W1992043883 hasConcept C55493867 @default.
• W1992043883 hasConcept C67705224 @default.
• W1992043883 hasConcept C71240020 @default.
• W1992043883 hasConcept C8010536 @default.
• W1992043883 hasConcept C86803240 @default.
• W1992043883 hasConcept C88478588 @default.
• W1992043883 hasConceptScore W1992043883C104317684 @default.
• W1992043883 hasConceptScore W1992043883C106774688 @default.
• W1992043883 hasConceptScore W1992043883C153957851 @default.
• W1992043883 hasConceptScore W1992043883C185581394 @default.
• W1992043883 hasConceptScore W1992043883C185592680 @default.
• W1992043883 hasConceptScore W1992043883C2776023528 @default.
• W1992043883 hasConceptScore W1992043883C512185932 @default.
• W1992043883 hasConceptScore W1992043883C547475151 @default.
• W1992043883 hasConceptScore W1992043883C552990157 @default.
• W1992043883 hasConceptScore W1992043883C55493867 @default.
• W1992043883 hasConceptScore W1992043883C67705224 @default.
• W1992043883 hasConceptScore W1992043883C71240020 @default.
• W1992043883 hasConceptScore W1992043883C8010536 @default.
• W1992043883 hasConceptScore W1992043883C86803240 @default.
• W1992043883 hasConceptScore W1992043883C88478588 @default.
• W1992043883 hasIssue "1" @default.
• W1992043883 hasLocation W19920438831 @default.
• W1992043883 hasLocation W19920438832 @default.
• W1992043883 hasOpenAccess W1992043883 @default.
• W1992043883 hasPrimaryLocation W19920438831 @default.
• W1992043883 hasRelatedWork W1975455557 @default.
• W1992043883 hasRelatedWork W1992043883 @default.

• next