FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992048688> ?p ?o ?g. }

• W1992048688 endingPage "e33061" @default.
• W1992048688 startingPage "e33061" @default.
• W1992048688 abstract "Tuberculosis (TB) remains the most frequent cause of illness and death from an infectious agent, and its interaction with HIV has devastating effects. We determined plasma levels of dehydroepiandrosterone (DHEA), its circulating form DHEA-suphate (DHEA-s) and cortisol in different stages of M. tuberculosis infection, and explored their role on the Th1 and Treg populations during different scenarios of HIV-TB coinfection, including the immune reconstitution inflammatory syndrome (IRIS), a condition related to antiretroviral treatment. DHEA levels were diminished in HIV-TB and HIV-TB IRIS patients compared to healthy donors (HD), HIV+ individuals and HIV+ individuals with latent TB (HIV-LTB), whereas dehydroepiandrosterone sulfate (DHEA-s) levels were markedly diminished in HIV-TB IRIS individuals. HIV-TB and IRIS patients presented a cortisol/DHEA ratio significantly higher than HIV+, HIV-LTB and HD individuals. A positive correlation was observed between DHEA-s and CD4 count among HIV-TB individuals. Conversely, cortisol plasma level inversely correlated with CD4 count within HIV-TB individuals. M. tuberculosis-specific Th1 lymphocyte count was increased after culturing PBMC from HIV-TB individuals in presence of DHEA. We observed an inverse correlation between DHEA-s plasma level and Treg frequency in co-infected individuals, and CD4+FoxP3+ Treg frequency was increased in HIV-TB and IRIS patients compared to other groups. Strikingly, we observed a prominent CD4+CD25-FoxP3+ population across HIV-TB and HIV-TB IRIS patients, which frequency correlated with DHEA plasma level. Finally, DHEA treatment negatively regulated FoxP3 expression without altering Treg frequency in co-infected patients. These data suggest an enhancing role for DHEA in the immune response against M. tuberculosis during HIV-TB coinfection and IRIS." @default.
• W1992048688 created "2016-06-24" @default.
• W1992048688 creator A5005806963 @default.
• W1992048688 creator A5030080152 @default.
• W1992048688 creator A5040675728 @default.
• W1992048688 creator A5047822911 @default.
• W1992048688 creator A5047852129 @default.
• W1992048688 creator A5054575453 @default.
• W1992048688 creator A5056295795 @default.
• W1992048688 creator A5061001592 @default.
• W1992048688 creator A5061097917 @default.
• W1992048688 creator A5064118146 @default.
• W1992048688 date "2012-03-14" @default.
• W1992048688 modified "2023-09-26" @default.
• W1992048688 title "Dynamics of Adrenal Steroids Are Related to Variations in Th1 and Treg Populations during Mycobacterium tuberculosis Infection in HIV Positive Persons" @default.
• W1992048688 cites W1480442635 @default.
• W1992048688 cites W1582329765 @default.
• W1992048688 cites W1898342479 @default.
• W1992048688 cites W1965537920 @default.
• W1992048688 cites W1968206416 @default.
• W1992048688 cites W1978146427 @default.
• W1992048688 cites W1980084527 @default.
• W1992048688 cites W1980959717 @default.
• W1992048688 cites W1989700749 @default.
• W1992048688 cites W1991600170 @default.
• W1992048688 cites W1992037894 @default.
• W1992048688 cites W1998086688 @default.
• W1992048688 cites W2003673147 @default.
• W1992048688 cites W2005535905 @default.
• W1992048688 cites W2006955905 @default.
• W1992048688 cites W2014615053 @default.
• W1992048688 cites W2018129368 @default.
• W1992048688 cites W2020214471 @default.
• W1992048688 cites W2026787011 @default.
• W1992048688 cites W2030883261 @default.
• W1992048688 cites W2033330275 @default.
• W1992048688 cites W2036774036 @default.
• W1992048688 cites W2046276816 @default.
• W1992048688 cites W2050875299 @default.
• W1992048688 cites W2053302471 @default.
• W1992048688 cites W2057185057 @default.
• W1992048688 cites W2057735692 @default.
• W1992048688 cites W2059678333 @default.
• W1992048688 cites W2063442011 @default.
• W1992048688 cites W2072853625 @default.
• W1992048688 cites W2078953178 @default.
• W1992048688 cites W2082759302 @default.
• W1992048688 cites W2085132811 @default.
• W1992048688 cites W2115856669 @default.
• W1992048688 cites W2116654815 @default.
• W1992048688 cites W2120074558 @default.
• W1992048688 cites W2122544370 @default.
• W1992048688 cites W2132845032 @default.
• W1992048688 cites W2133394512 @default.
• W1992048688 cites W2142922417 @default.
• W1992048688 cites W2148847506 @default.
• W1992048688 cites W2160552059 @default.
• W1992048688 cites W2161784221 @default.
• W1992048688 cites W2162656915 @default.
• W1992048688 cites W2163625719 @default.
• W1992048688 cites W4210457135 @default.
• W1992048688 cites W4211162439 @default.
• W1992048688 doi "https://doi.org/10.1371/journal.pone.0033061" @default.
• W1992048688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3303789" @default.
• W1992048688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22431997" @default.
• W1992048688 hasPublicationYear "2012" @default.
• W1992048688 type Work @default.
• W1992048688 sameAs 1992048688 @default.
• W1992048688 citedByCount "17" @default.
• W1992048688 countsByYear W19920486882013 @default.
• W1992048688 countsByYear W19920486882015 @default.
• W1992048688 countsByYear W19920486882017 @default.
• W1992048688 countsByYear W19920486882018 @default.
• W1992048688 countsByYear W19920486882019 @default.
• W1992048688 countsByYear W19920486882020 @default.
• W1992048688 countsByYear W19920486882021 @default.
• W1992048688 countsByYear W19920486882022 @default.
• W1992048688 countsByYear W19920486882023 @default.
• W1992048688 crossrefType "journal-article" @default.
• W1992048688 hasAuthorship W1992048688A5005806963 @default.
• W1992048688 hasAuthorship W1992048688A5030080152 @default.
• W1992048688 hasAuthorship W1992048688A5040675728 @default.
• W1992048688 hasAuthorship W1992048688A5047822911 @default.
• W1992048688 hasAuthorship W1992048688A5047852129 @default.
• W1992048688 hasAuthorship W1992048688A5054575453 @default.
• W1992048688 hasAuthorship W1992048688A5056295795 @default.
• W1992048688 hasAuthorship W1992048688A5061001592 @default.
• W1992048688 hasAuthorship W1992048688A5061097917 @default.
• W1992048688 hasAuthorship W1992048688A5064118146 @default.
• W1992048688 hasBestOaLocation W19920486881 @default.
• W1992048688 hasConcept C126322002 @default.
• W1992048688 hasConcept C142462285 @default.
• W1992048688 hasConcept C142724271 @default.
• W1992048688 hasConcept C203014093 @default.
• W1992048688 hasConcept C2776992908 @default.
• W1992048688 hasConcept C2777813720 @default.
• W1992048688 hasConcept C2777911890 @default.
• W1992048688 hasConcept C2777975735 @default.

• next