Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992051330> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1992051330 endingPage "2644" @default.
- W1992051330 startingPage "2639" @default.
- W1992051330 abstract "A study of the quantitative structure activity relationships (QSARs) was performed based on the binding affinity (pKi) values of 32 protein kinase C (PK-C) ligands. The QSAR study was carried out by using both three-dimensional descriptors (the steric and electrostatic CoMFA fields) and the physicochemical properties (logP values). The CoMFA analysis provided a reasonable QSAR model, with a cross-validated q2 value of 0.671 and a conventional r2 value of 0.956, which was confirmed by the satisfactory prediction of the experimental binding affinity (pKi) values for a series of 3-alkylidene-5,5-disubstituted tetrahydro-2-furanones included in the test set. The resultant QSAR model will be useful for designing highly potent and selective PK-C ligands." @default.
- W1992051330 created "2016-06-24" @default.
- W1992051330 creator A5000439028 @default.
- W1992051330 creator A5030341663 @default.
- W1992051330 date "2004-05-01" @default.
- W1992051330 modified "2023-09-25" @default.
- W1992051330 title "3D-QSAR analysis of conformationally constrained diacylglycerol (DAG) analogues as potent protein kinase C (PK-C) ligands" @default.
- W1992051330 cites W1491958169 @default.
- W1992051330 cites W1525229364 @default.
- W1992051330 cites W1777807410 @default.
- W1992051330 cites W1971470826 @default.
- W1992051330 cites W1978265027 @default.
- W1992051330 cites W1980854090 @default.
- W1992051330 cites W1989165494 @default.
- W1992051330 cites W2007550845 @default.
- W1992051330 cites W2008272325 @default.
- W1992051330 cites W2013056904 @default.
- W1992051330 cites W2015073280 @default.
- W1992051330 cites W2017641795 @default.
- W1992051330 cites W2039307312 @default.
- W1992051330 cites W2086524338 @default.
- W1992051330 cites W2091502073 @default.
- W1992051330 cites W2115544008 @default.
- W1992051330 cites W2163421864 @default.
- W1992051330 doi "https://doi.org/10.1016/j.bmc.2004.03.016" @default.
- W1992051330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15110845" @default.
- W1992051330 hasPublicationYear "2004" @default.
- W1992051330 type Work @default.
- W1992051330 sameAs 1992051330 @default.
- W1992051330 citedByCount "2" @default.
- W1992051330 countsByYear W19920513302013 @default.
- W1992051330 countsByYear W19920513302016 @default.
- W1992051330 crossrefType "journal-article" @default.
- W1992051330 hasAuthorship W1992051330A5000439028 @default.
- W1992051330 hasAuthorship W1992051330A5030341663 @default.
- W1992051330 hasConcept C164126121 @default.
- W1992051330 hasConcept C178910836 @default.
- W1992051330 hasConcept C184235292 @default.
- W1992051330 hasConcept C185592680 @default.
- W1992051330 hasConcept C195794163 @default.
- W1992051330 hasConcept C201194858 @default.
- W1992051330 hasConcept C36020004 @default.
- W1992051330 hasConcept C55493867 @default.
- W1992051330 hasConcept C71240020 @default.
- W1992051330 hasConceptScore W1992051330C164126121 @default.
- W1992051330 hasConceptScore W1992051330C178910836 @default.
- W1992051330 hasConceptScore W1992051330C184235292 @default.
- W1992051330 hasConceptScore W1992051330C185592680 @default.
- W1992051330 hasConceptScore W1992051330C195794163 @default.
- W1992051330 hasConceptScore W1992051330C201194858 @default.
- W1992051330 hasConceptScore W1992051330C36020004 @default.
- W1992051330 hasConceptScore W1992051330C55493867 @default.
- W1992051330 hasConceptScore W1992051330C71240020 @default.
- W1992051330 hasIssue "10" @default.
- W1992051330 hasLocation W19920513301 @default.
- W1992051330 hasLocation W19920513302 @default.
- W1992051330 hasOpenAccess W1992051330 @default.
- W1992051330 hasPrimaryLocation W19920513301 @default.
- W1992051330 hasRelatedWork W1981269287 @default.
- W1992051330 hasRelatedWork W1992051330 @default.
- W1992051330 hasRelatedWork W1996640807 @default.
- W1992051330 hasRelatedWork W2003226093 @default.
- W1992051330 hasRelatedWork W2018302727 @default.
- W1992051330 hasRelatedWork W2030067016 @default.
- W1992051330 hasRelatedWork W2068584446 @default.
- W1992051330 hasRelatedWork W2091806755 @default.
- W1992051330 hasRelatedWork W2093154530 @default.
- W1992051330 hasRelatedWork W2094630932 @default.
- W1992051330 hasVolume "12" @default.
- W1992051330 isParatext "false" @default.
- W1992051330 isRetracted "false" @default.
- W1992051330 magId "1992051330" @default.
- W1992051330 workType "article" @default.