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- W1992052022 endingPage "57" @default.
- W1992052022 startingPage "49" @default.
- W1992052022 abstract "The brain of the infant and young child is a developing, dynamic, structure subject to functional remodelling under the influence of factors responsible for optimal neuronal development and synaptogenesis. It exhibits age dependent variation in metabolic rate, blood flow, and ability to tolerate oxidative stress. It is also characterized by an exuberance of neurotransmitter activity, particularly in the first few years of life. The dynamic evolution and adaptability of early brain function permits the organization of neuronal networks to be influenced by environmental stimulation, and, to reduce the functional impact of injury. However, these same processes may also exacerbate the harm sustained by the brain following an acquired brain injury (ABI). The developing neurons are susceptible to excitotoxicity, oxidative stress, and, inflammation, often leading to cellular necrosis and apoptosis. Despite being immunologically privileged via the blood brain barrier, the developing brain is susceptible to injury from systemic inflammation through alteration of normally protective cerebrovascular endothelial cell function. Finally, many of the therapeutic agents currently employed in post-ABI hospital care may also compromise ABI outcome via non-intended pharmacological effects. These agents include analgesic, sedative and anti-convulsant medications. This review emphasizes those physiological considerations in the developing brain which may impact the outcome after ABI, including, the cellular mechanisms of neuronal and cerebrovascular endothelial cell injury, ABI outcome and future therapeutic directions." @default.
- W1992052022 created "2016-06-24" @default.
- W1992052022 creator A5021877357 @default.
- W1992052022 creator A5034090835 @default.
- W1992052022 creator A5039959034 @default.
- W1992052022 date "2013-02-01" @default.
- W1992052022 modified "2023-09-30" @default.
- W1992052022 title "Mechanisms and consequences of acquired brain injury during development" @default.
- W1992052022 cites W1491554659 @default.
- W1992052022 cites W185892090 @default.
- W1992052022 cites W1895508641 @default.
- W1992052022 cites W1965476204 @default.
- W1992052022 cites W1970263371 @default.
- W1992052022 cites W1972876716 @default.
- W1992052022 cites W1973067179 @default.
- W1992052022 cites W1976210749 @default.
- W1992052022 cites W1978726693 @default.
- W1992052022 cites W1981040687 @default.
- W1992052022 cites W1983249739 @default.
- W1992052022 cites W1986394834 @default.
- W1992052022 cites W1988166648 @default.
- W1992052022 cites W1990518612 @default.
- W1992052022 cites W1991838553 @default.
- W1992052022 cites W1994842806 @default.
- W1992052022 cites W1997010751 @default.
- W1992052022 cites W1999485470 @default.
- W1992052022 cites W1999495417 @default.
- W1992052022 cites W1999675886 @default.
- W1992052022 cites W2000965529 @default.
- W1992052022 cites W2005401338 @default.
- W1992052022 cites W2008944418 @default.
- W1992052022 cites W2009178440 @default.
- W1992052022 cites W2009765224 @default.
- W1992052022 cites W2019564700 @default.
- W1992052022 cites W2022746025 @default.
- W1992052022 cites W2024263926 @default.
- W1992052022 cites W2024283264 @default.
- W1992052022 cites W2025128734 @default.
- W1992052022 cites W2025676338 @default.
- W1992052022 cites W2028031080 @default.
- W1992052022 cites W2028189293 @default.
- W1992052022 cites W2030999499 @default.
- W1992052022 cites W2031981004 @default.
- W1992052022 cites W2034184269 @default.
- W1992052022 cites W2035084522 @default.
- W1992052022 cites W2035873736 @default.
- W1992052022 cites W2036127369 @default.
- W1992052022 cites W2036650593 @default.
- W1992052022 cites W2038470517 @default.
- W1992052022 cites W2038691367 @default.
- W1992052022 cites W2040646335 @default.
- W1992052022 cites W2040788869 @default.
- W1992052022 cites W2041456603 @default.
- W1992052022 cites W2041933034 @default.
- W1992052022 cites W2044565737 @default.
- W1992052022 cites W2045180954 @default.
- W1992052022 cites W2046460375 @default.
- W1992052022 cites W2048352834 @default.
- W1992052022 cites W2048406001 @default.
- W1992052022 cites W2049806528 @default.
- W1992052022 cites W2050571955 @default.
- W1992052022 cites W2051395367 @default.
- W1992052022 cites W2053009200 @default.
- W1992052022 cites W2055004294 @default.
- W1992052022 cites W2055609777 @default.
- W1992052022 cites W2056433162 @default.
- W1992052022 cites W2056475298 @default.
- W1992052022 cites W2057252526 @default.
- W1992052022 cites W2057643090 @default.
- W1992052022 cites W2058370142 @default.
- W1992052022 cites W2058977770 @default.
- W1992052022 cites W2068091349 @default.
- W1992052022 cites W2068896673 @default.
- W1992052022 cites W2071031454 @default.
- W1992052022 cites W2073526291 @default.
- W1992052022 cites W2075782105 @default.
- W1992052022 cites W2082141491 @default.
- W1992052022 cites W2087753404 @default.
- W1992052022 cites W2088027239 @default.
- W1992052022 cites W2090969188 @default.
- W1992052022 cites W2091423085 @default.
- W1992052022 cites W2092146469 @default.
- W1992052022 cites W2094845658 @default.
- W1992052022 cites W2096730504 @default.
- W1992052022 cites W2097924742 @default.
- W1992052022 cites W2098951649 @default.
- W1992052022 cites W2099929136 @default.
- W1992052022 cites W2104629966 @default.
- W1992052022 cites W2104968232 @default.
- W1992052022 cites W2105455720 @default.
- W1992052022 cites W2109759840 @default.
- W1992052022 cites W2113570143 @default.
- W1992052022 cites W2119985051 @default.
- W1992052022 cites W2121875633 @default.
- W1992052022 cites W2123565134 @default.
- W1992052022 cites W2126888533 @default.
- W1992052022 cites W2129985526 @default.
- W1992052022 cites W2133745591 @default.