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• W1992055985 abstract "Homocamptothecins (hCPTs) represents a new promising class of topoisomerase I inhibitors with enhanced stability and superior antitumor activity. Some phosphodiesters and phosphotriesters homocamptothecin derivatives were designed and synthesized based on our previous synthetic route. The cytotoxicity in vitro on three cancer cell lines and antitumor activity in vivo, and inhibitory properties of topoisomerase I of these derivatives were evaluated. Among them compounds 24e and 24f exhibited higher cytotoxic activity than IRT and the former exhibited the best antitumor activity in vivo and solution stability both at pH 7.4 and pH 3.0." @default.
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• W1992055985 date "2010-05-01" @default.
• W1992055985 modified "2023-10-15" @default.
• W1992055985 title "Phosphate ester derivatives of homocamptothecin: Synthesis, solution stabilities and antitumor activities" @default.
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• W1992055985 doi "https://doi.org/10.1016/j.bmc.2010.03.039" @default.
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