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- W1992056659 abstract "The transforming growth factor-beta (TGF-beta) superfamily comprises more than 40 members, classified on the basis of structural similarity. These factors elicit a diverse range of cellular responses in insects, nematodes and vertebrates, via serine/threonine kinase receptors and intracellular Smad proteins, which when activated mediate gene transcription. Some members of the superfamily, notably activin, TGF-beta, GDF-9 and the bone morphogenetic proteins have been shown to influence ovarian function. Despite these actions, TGF-beta superfamily signalling pathways and specifically those within follicle population subtypes, have been poorly characterised in the ovary. We have shown that the ovary contains type I and II receptors and Smads, which enable it to transduce signals in response to TGF-beta superfamily members. It remains to be established however, as to which follicle subtypes these pathways are active in." @default.
- W1992056659 created "2016-06-24" @default.
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- W1992056659 date "2003-04-01" @default.
- W1992056659 modified "2023-09-26" @default.
- W1992056659 title "Ovarian follicle populations of the rat express TGF-β signalling pathways" @default.
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- W1992056659 doi "https://doi.org/10.1016/s0303-7207(03)00062-5" @default.
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