FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992057102> ?p ?o ?g. }

• W1992057102 endingPage "1672" @default.
• W1992057102 startingPage "1662" @default.
• W1992057102 abstract "Escherichia coli that express Dr fimbriae and related adhesins recognize the common receptor decay accelerating factor. E. coli strains that express adhesins of the Dr family were postulated to be associated with cystitis (30-50%), pregnancy-associated pyelonephritis (30%), and chronic diarrhea (50%). In this study, we investigated the hypothesis that E. coli renal interstitial binding mediated by the Dr adhesin may be important for the development of chronic pyelonephritis. An insertional dra mutant, E. coli DR14, of the clinical E. coli isolate IH11128 bearing Dr fimbriae, was constructed and used to characterize persistence of infection and interstitial tropism in an experimental model of ascending pyelonephritis. Quantitative cultures of kidney homogenates indicated that Dr hemagglutinin positive (Dr+) E. coli IH11128 established a 1-yr colonization of renal tissue. In the Dr hemagglutinin negative (Dr-) group, 50% of animals cleared infection within 20 wk and 100% between 32 to 52 wk. Dr+ E. coli colonized the renal interstitium. Significant histological changes corresponding to tubulointerstitial nephritis including interstitial inflammation, fibrosis, and tubular atrophy were found in the kidney tissue of the Dr+ but not the Dr- group. A substantial amount of fimbrial antigen was detected in the parenchymal regions affected by interstitial inflammation and fibrosis. The obtained results are consistent with the hypothesis that mutation within the dra region, affecting E. coli binding to tubular basement membranes, prevented renal interstitial tropism and the development of the changes characteristically seen in tubulointerstitial nephritis." @default.
• W1992057102 created "2016-06-24" @default.
• W1992057102 creator A5004745689 @default.
• W1992057102 creator A5014497218 @default.
• W1992057102 creator A5021152313 @default.
• W1992057102 creator A5036768172 @default.
• W1992057102 creator A5040152113 @default.
• W1992057102 creator A5053267770 @default.
• W1992057102 creator A5083409230 @default.
• W1992057102 creator A5091792370 @default.
• W1992057102 date "1997-04-01" @default.
• W1992057102 modified "2023-10-10" @default.
• W1992057102 title "Development of experimental model of chronic pyelonephritis with Escherichia coli O75:K5:H-bearing Dr fimbriae: mutation in the dra region prevented tubulointerstitial nephritis." @default.
• W1992057102 cites W1518190076 @default.
• W1992057102 cites W1520914849 @default.
• W1992057102 cites W1534408834 @default.
• W1992057102 cites W1535383467 @default.
• W1992057102 cites W1787690277 @default.
• W1992057102 cites W1810569172 @default.
• W1992057102 cites W1812884807 @default.
• W1992057102 cites W1842434561 @default.
• W1992057102 cites W1854822574 @default.
• W1992057102 cites W1854995442 @default.
• W1992057102 cites W1917629533 @default.
• W1992057102 cites W1919353978 @default.
• W1992057102 cites W1919890156 @default.
• W1992057102 cites W1927767888 @default.
• W1992057102 cites W1965125389 @default.
• W1992057102 cites W1968082009 @default.
• W1992057102 cites W1981966712 @default.
• W1992057102 cites W2044598761 @default.
• W1992057102 cites W2068770357 @default.
• W1992057102 cites W2075419819 @default.
• W1992057102 cites W2081210113 @default.
• W1992057102 cites W2088296498 @default.
• W1992057102 cites W2089608808 @default.
• W1992057102 cites W2103368250 @default.
• W1992057102 cites W2113814578 @default.
• W1992057102 cites W2114920539 @default.
• W1992057102 cites W2123779514 @default.
• W1992057102 cites W2133906658 @default.
• W1992057102 cites W2143302748 @default.
• W1992057102 cites W2144498842 @default.
• W1992057102 cites W2153432843 @default.
• W1992057102 cites W2167578487 @default.
• W1992057102 doi "https://doi.org/10.1172/jci119329" @default.
• W1992057102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/507986" @default.
• W1992057102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9120010" @default.
• W1992057102 hasPublicationYear "1997" @default.
• W1992057102 type Work @default.
• W1992057102 sameAs 1992057102 @default.
• W1992057102 citedByCount "117" @default.
• W1992057102 countsByYear W19920571022012 @default.
• W1992057102 countsByYear W19920571022013 @default.
• W1992057102 countsByYear W19920571022014 @default.
• W1992057102 countsByYear W19920571022015 @default.
• W1992057102 countsByYear W19920571022016 @default.
• W1992057102 countsByYear W19920571022017 @default.
• W1992057102 countsByYear W19920571022018 @default.
• W1992057102 countsByYear W19920571022019 @default.
• W1992057102 countsByYear W19920571022022 @default.
• W1992057102 crossrefType "journal-article" @default.
• W1992057102 hasAuthorship W1992057102A5004745689 @default.
• W1992057102 hasAuthorship W1992057102A5014497218 @default.
• W1992057102 hasAuthorship W1992057102A5021152313 @default.
• W1992057102 hasAuthorship W1992057102A5036768172 @default.
• W1992057102 hasAuthorship W1992057102A5040152113 @default.
• W1992057102 hasAuthorship W1992057102A5053267770 @default.
• W1992057102 hasAuthorship W1992057102A5083409230 @default.
• W1992057102 hasAuthorship W1992057102A5091792370 @default.
• W1992057102 hasBestOaLocation W19920571021 @default.
• W1992057102 hasConcept C104317684 @default.
• W1992057102 hasConcept C134018914 @default.
• W1992057102 hasConcept C179470777 @default.
• W1992057102 hasConcept C203014093 @default.
• W1992057102 hasConcept C2522874641 @default.
• W1992057102 hasConcept C2777058396 @default.
• W1992057102 hasConcept C2780091579 @default.
• W1992057102 hasConcept C2780888721 @default.
• W1992057102 hasConcept C35693153 @default.
• W1992057102 hasConcept C39103817 @default.
• W1992057102 hasConcept C547475151 @default.
• W1992057102 hasConcept C55493867 @default.
• W1992057102 hasConcept C86803240 @default.
• W1992057102 hasConcept C89423630 @default.
• W1992057102 hasConceptScore W1992057102C104317684 @default.
• W1992057102 hasConceptScore W1992057102C134018914 @default.
• W1992057102 hasConceptScore W1992057102C179470777 @default.
• W1992057102 hasConceptScore W1992057102C203014093 @default.
• W1992057102 hasConceptScore W1992057102C2522874641 @default.
• W1992057102 hasConceptScore W1992057102C2777058396 @default.
• W1992057102 hasConceptScore W1992057102C2780091579 @default.
• W1992057102 hasConceptScore W1992057102C2780888721 @default.
• W1992057102 hasConceptScore W1992057102C35693153 @default.
• W1992057102 hasConceptScore W1992057102C39103817 @default.
• W1992057102 hasConceptScore W1992057102C547475151 @default.
• W1992057102 hasConceptScore W1992057102C55493867 @default.
• W1992057102 hasConceptScore W1992057102C86803240 @default.

• next