Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992059613> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W1992059613 abstract "Thalidomide is known to be effective in the treatment of a number of conditions, including leprosy and various cancers. The exact mechanisms of action remain unclear although these are known to include anti-tumour necrosis factor (TNF)-alpha, T cell costimulatory, anti-angiogenic and anti-tumour activities. However, thalidomide is being superceded by novel structural derivatives which have been designed to have improved immunomodulatory activity and side effect profiles. These are currently being characterised and some are entering the clinic in phase I/II studies. One novel group of structural analogues are classified as the Immunomodulatory Drugs (IMiDs). This review describes the emerging immunological, anti-angiogenic and direct anti-tumour properties of thalidomide and the characterisation and clinical application of its IMiD analogues. We describe the laboratory studies which have led to the characterisation and development of IMiDs into potentially clinically relevant drugs. Early trial data suggests that these compounds may themselves become established therapies, particularly in certain cancers. Furthermore, ongoing studies will determine how best to apply these compounds to the appropriate clinical settings. We will describe the various clinical studies of lead compounds that are in progress and speculate as to the potential and future development of these exciting compounds." @default.
- W1992059613 created "2016-06-24" @default.
- W1992059613 creator A5037701750 @default.
- W1992059613 creator A5061208744 @default.
- W1992059613 creator A5067606220 @default.
- W1992059613 date "2003-09-01" @default.
- W1992059613 modified "2023-09-27" @default.
- W1992059613 title "Thalidomide Derived Immunomodulatory Drugs (IMiDs) as Potential Therapeutic Agents" @default.
- W1992059613 doi "https://doi.org/10.2174/1568008033340207" @default.
- W1992059613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12871024" @default.
- W1992059613 hasPublicationYear "2003" @default.
- W1992059613 type Work @default.
- W1992059613 sameAs 1992059613 @default.
- W1992059613 citedByCount "16" @default.
- W1992059613 countsByYear W19920596132013 @default.
- W1992059613 countsByYear W19920596132014 @default.
- W1992059613 countsByYear W19920596132015 @default.
- W1992059613 countsByYear W19920596132016 @default.
- W1992059613 countsByYear W19920596132017 @default.
- W1992059613 countsByYear W19920596132021 @default.
- W1992059613 crossrefType "journal-article" @default.
- W1992059613 hasAuthorship W1992059613A5037701750 @default.
- W1992059613 hasAuthorship W1992059613A5061208744 @default.
- W1992059613 hasAuthorship W1992059613A5067606220 @default.
- W1992059613 hasConcept C126322002 @default.
- W1992059613 hasConcept C203014093 @default.
- W1992059613 hasConcept C2776364478 @default.
- W1992059613 hasConcept C2779609412 @default.
- W1992059613 hasConcept C502942594 @default.
- W1992059613 hasConcept C535046627 @default.
- W1992059613 hasConcept C60644358 @default.
- W1992059613 hasConcept C71924100 @default.
- W1992059613 hasConcept C86803240 @default.
- W1992059613 hasConcept C98274493 @default.
- W1992059613 hasConceptScore W1992059613C126322002 @default.
- W1992059613 hasConceptScore W1992059613C203014093 @default.
- W1992059613 hasConceptScore W1992059613C2776364478 @default.
- W1992059613 hasConceptScore W1992059613C2779609412 @default.
- W1992059613 hasConceptScore W1992059613C502942594 @default.
- W1992059613 hasConceptScore W1992059613C535046627 @default.
- W1992059613 hasConceptScore W1992059613C60644358 @default.
- W1992059613 hasConceptScore W1992059613C71924100 @default.
- W1992059613 hasConceptScore W1992059613C86803240 @default.
- W1992059613 hasConceptScore W1992059613C98274493 @default.
- W1992059613 hasLocation W19920596131 @default.
- W1992059613 hasLocation W19920596132 @default.
- W1992059613 hasOpenAccess W1992059613 @default.
- W1992059613 hasPrimaryLocation W19920596131 @default.
- W1992059613 hasRelatedWork W2072932634 @default.
- W1992059613 hasRelatedWork W2084954901 @default.
- W1992059613 hasRelatedWork W2093544430 @default.
- W1992059613 hasRelatedWork W2114407565 @default.
- W1992059613 hasRelatedWork W2380970042 @default.
- W1992059613 hasRelatedWork W2899084033 @default.
- W1992059613 hasRelatedWork W2899932248 @default.
- W1992059613 hasRelatedWork W2953271378 @default.
- W1992059613 hasRelatedWork W4236735901 @default.
- W1992059613 hasRelatedWork W4247728950 @default.
- W1992059613 isParatext "false" @default.
- W1992059613 isRetracted "false" @default.
- W1992059613 magId "1992059613" @default.
- W1992059613 workType "article" @default.