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• W1992060814 abstract "This report provides a review of early and late effects of radiation in normal tissues and organs with respect to radiation protection. It was instigated following a recommendation in Publication 103 (ICRP, 2007), and it provides updated estimates of ‘practical’ threshold doses for tissue injury defined at the level of 1% incidence. Estimates are given for morbidity and mortality endpoints in all organ systems following acute, fractionated, or chronic exposure. The organ systems comprise the haematopoietic, immune, reproductive, circulatory, respiratory, musculoskeletal, endocrine, and nervous systems; the digestive and urinary tracts; the skin; and the eye. Particular attention is paid to circulatory disease and cataracts because of recent evidence of higher incidences of injury than expected after lower doses; hence, threshold doses appear to be lower than previously considered. This is largely because of the increasing incidences with increasing times after exposure. In the context of protection, it is the threshold doses for very long follow-up times that are the most relevant for workers and the public; for example, the atomic bomb survivors with 40–50 years of follow-up. Radiotherapy data generally apply for shorter follow-up times because of competing causes of death in cancer patients, and hence the risks of radiation-induced circulatory disease at those earlier times are lower. A variety of biological response modifiers have been used to help reduce late reactions in many tissues. These include antioxidants, radical scavengers, inhibitors of apoptosis, anti-inflammatory drugs, angiotensin-converting enzyme inhibitors, growth factors, and cytokines. In many cases, these give dose modification factors of 1.1–1.2, and in a few cases 1.5–2, indicating the potential for increasing threshold doses in known exposure cases. In contrast, there are agents that enhance radiation responses, notably other cytotoxic agents such as antimetabolites, alkylating agents, anti-angiogenic drugs, and antibiotics, as well as genetic and comorbidity factors. Most tissues show a sparing effect of dose fractionation, so that total doses for a given endpoint are higher if the dose is fractionated rather than when given as a single dose. However, for reactions manifesting very late after low total doses, particularly for cataracts and circulatory disease, it appears that the rate of dose delivery does not modify the low incidence. This implies that the injury in these cases and at these low dose levels is caused by single-hit irreparable-type events. For these two tissues, a threshold dose of 0.5 Gy is proposed herein for practical purposes, irrespective of the rate of dose delivery, and future studies may elucidate this judgement further." @default.
• W1992060814 created "2016-06-24" @default.
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• W1992060814 date "2012-02-01" @default.
• W1992060814 modified "2023-10-18" @default.
• W1992060814 title "ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs — Threshold Doses for Tissue Reactions in a Radiation Protection Context" @default.
• W1992060814 cites W1135230176 @default.
• W1992060814 cites W118551320 @default.
• W1992060814 cites W122790944 @default.
• W1992060814 cites W133062420 @default.
• W1992060814 cites W139223721 @default.
• W1992060814 cites W1428480121 @default.
• W1992060814 cites W146687376 @default.
• W1992060814 cites W148055779 @default.
• W1992060814 cites W1482463931 @default.
• W1992060814 cites W1483856048 @default.
• W1992060814 cites W1493554182 @default.
• W1992060814 cites W149739268 @default.
• W1992060814 cites W1505324034 @default.
• W1992060814 cites W1508142507 @default.
• W1992060814 cites W1525488943 @default.
• W1992060814 cites W1529490909 @default.
• W1992060814 cites W1530057448 @default.
• W1992060814 cites W1539655054 @default.
• W1992060814 cites W1541138563 @default.
• W1992060814 cites W1543299842 @default.
• W1992060814 cites W1557071782 @default.
• W1992060814 cites W1560590901 @default.
• W1992060814 cites W1565328962 @default.
• W1992060814 cites W1570743730 @default.
• W1992060814 cites W1577454575 @default.
• W1992060814 cites W1578873522 @default.
• W1992060814 cites W1582722466 @default.
• W1992060814 cites W1586437797 @default.
• W1992060814 cites W1588053363 @default.
• W1992060814 cites W1595815978 @default.
• W1992060814 cites W1600360981 @default.
• W1992060814 cites W1608141030 @default.
• W1992060814 cites W163635259 @default.
• W1992060814 cites W165253497 @default.
• W1992060814 cites W1833330468 @default.
• W1992060814 cites W183917128 @default.
• W1992060814 cites W1844928704 @default.
• W1992060814 cites W1876031147 @default.
• W1992060814 cites W1893260165 @default.
• W1992060814 cites W1901986041 @default.
• W1992060814 cites W191518160 @default.
• W1992060814 cites W1930328171 @default.
• W1992060814 cites W1936380547 @default.
• W1992060814 cites W1952579501 @default.
• W1992060814 cites W1964053501 @default.
• W1992060814 cites W1964306807 @default.
• W1992060814 cites W1964679019 @default.
• W1992060814 cites W1964759286 @default.
• W1992060814 cites W1964834425 @default.
• W1992060814 cites W1965234452 @default.
• W1992060814 cites W1965286374 @default.
• W1992060814 cites W1965425745 @default.
• W1992060814 cites W1965603638 @default.
• W1992060814 cites W1965706580 @default.
• W1992060814 cites W1965915798 @default.
• W1992060814 cites W1965920084 @default.
• W1992060814 cites W1966051677 @default.
• W1992060814 cites W1966570723 @default.
• W1992060814 cites W1966768984 @default.
• W1992060814 cites W1966825452 @default.
• W1992060814 cites W1966854534 @default.
• W1992060814 cites W1967082464 @default.
• W1992060814 cites W1967374051 @default.
• W1992060814 cites W1967477415 @default.
• W1992060814 cites W1967648894 @default.
• W1992060814 cites W1967964269 @default.
• W1992060814 cites W1968395393 @default.
• W1992060814 cites W1968433117 @default.
• W1992060814 cites W1968773549 @default.
• W1992060814 cites W1968782107 @default.
• W1992060814 cites W1969079494 @default.
• W1992060814 cites W1969626495 @default.
• W1992060814 cites W1969956601 @default.
• W1992060814 cites W1970029658 @default.
• W1992060814 cites W1970199815 @default.
• W1992060814 cites W1970291858 @default.
• W1992060814 cites W1970950893 @default.
• W1992060814 cites W1971164307 @default.
• W1992060814 cites W1971213586 @default.
• W1992060814 cites W1971413780 @default.
• W1992060814 cites W1971682080 @default.

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