FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992062620> ?p ?o ?g. }

• W1992062620 endingPage "154" @default.
• W1992062620 startingPage "149" @default.
• W1992062620 abstract "S-(Phenacyl)glutathione reductase (SPG-R) plays a significant role in the biotransformation of reactive alpha-haloketones to nontoxic acetophenones. Comparison of the apparent subunit size, amino acid composition, and catalysis of the reduction of S-(phenacyl)glutathiones indicated that a previously described rat SPG-R (Kitada, M., McLenithan, J. C., and Anders, M. W. (1985) J. Biol. Chem. 260, 11749-11754) is homologous to the omega-class glutathione transferase GSTO1-1. The available data show that the SPG-R reaction is catalyzed by GSTO1-1 and not by other GSTs, including the closely related GSTO2-2 isoenzyme. In the proposed reaction mechanism, the active-site cysteine residue of GSTO1-1 reacts with the S-(phenacyl)glutathione substrate to give an acetophenone and a mixed disulfide with the active-site cysteine; a second thiol substrate (e.g., glutathione or 2-mercaptoethanol) reacts with the active-site disulfide to regenerate the catalytically active enzyme and to form a mixed disulfide. A new spectrophotometric assay was developed that allows the rapid determination of SPG-R activity and specific measurement of GSTO1-1 in the presence of other GSTs. This is the first specific reaction attributed to GSTO1-1, and these results demonstrate the catalytic diversity of GSTO1-1, which, in addition to SPG-R activity, catalyzes the reduction of dehydroascorbate and monomethylarsonate(V) and also possesses thioltransferase and GST activity." @default.
• W1992062620 created "2016-06-24" @default.
• W1992062620 creator A5014130762 @default.
• W1992062620 creator A5022790249 @default.
• W1992062620 date "2006-12-24" @default.
• W1992062620 modified "2023-10-12" @default.
• W1992062620 title "Glutathione Transferase Omega 1 Catalyzes the Reduction of <i>S</i>-(Phenacyl)glutathiones to Acetophenones" @default.
• W1992062620 cites W11118004 @default.
• W1992062620 cites W1548250989 @default.
• W1992062620 cites W1581414347 @default.
• W1992062620 cites W1970242970 @default.
• W1992062620 cites W1970831257 @default.
• W1992062620 cites W1972238283 @default.
• W1992062620 cites W1975353423 @default.
• W1992062620 cites W1976690731 @default.
• W1992062620 cites W1989843181 @default.
• W1992062620 cites W1990994253 @default.
• W1992062620 cites W2032612723 @default.
• W1992062620 cites W2039095244 @default.
• W1992062620 cites W2061542733 @default.
• W1992062620 cites W2069063162 @default.
• W1992062620 cites W2074835372 @default.
• W1992062620 cites W2078452116 @default.
• W1992062620 cites W2091035358 @default.
• W1992062620 cites W2091427676 @default.
• W1992062620 cites W2098285182 @default.
• W1992062620 cites W2105010972 @default.
• W1992062620 cites W2128635872 @default.
• W1992062620 cites W2131937786 @default.
• W1992062620 cites W2410859377 @default.
• W1992062620 cites W2411768669 @default.
• W1992062620 cites W2443816042 @default.
• W1992062620 cites W4238581030 @default.
• W1992062620 cites W6733712 @default.
• W1992062620 doi "https://doi.org/10.1021/tx600305y" @default.
• W1992062620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2562259" @default.
• W1992062620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17226937" @default.
• W1992062620 hasPublicationYear "2006" @default.
• W1992062620 type Work @default.
• W1992062620 sameAs 1992062620 @default.
• W1992062620 citedByCount "61" @default.
• W1992062620 countsByYear W19920626202012 @default.
• W1992062620 countsByYear W19920626202013 @default.
• W1992062620 countsByYear W19920626202014 @default.
• W1992062620 countsByYear W19920626202015 @default.
• W1992062620 countsByYear W19920626202016 @default.
• W1992062620 countsByYear W19920626202017 @default.
• W1992062620 countsByYear W19920626202018 @default.
• W1992062620 countsByYear W19920626202019 @default.
• W1992062620 countsByYear W19920626202020 @default.
• W1992062620 countsByYear W19920626202021 @default.
• W1992062620 countsByYear W19920626202022 @default.
• W1992062620 countsByYear W19920626202023 @default.
• W1992062620 crossrefType "journal-article" @default.
• W1992062620 hasAuthorship W1992062620A5014130762 @default.
• W1992062620 hasAuthorship W1992062620A5022790249 @default.
• W1992062620 hasBestOaLocation W19920626202 @default.
• W1992062620 hasConcept C155647269 @default.
• W1992062620 hasConcept C181199279 @default.
• W1992062620 hasConcept C185592680 @default.
• W1992062620 hasConcept C2776907368 @default.
• W1992062620 hasConcept C2779201268 @default.
• W1992062620 hasConcept C2780570554 @default.
• W1992062620 hasConcept C2781324293 @default.
• W1992062620 hasConcept C41183919 @default.
• W1992062620 hasConcept C538909803 @default.
• W1992062620 hasConcept C55493867 @default.
• W1992062620 hasConcept C71240020 @default.
• W1992062620 hasConceptScore W1992062620C155647269 @default.
• W1992062620 hasConceptScore W1992062620C181199279 @default.
• W1992062620 hasConceptScore W1992062620C185592680 @default.
• W1992062620 hasConceptScore W1992062620C2776907368 @default.
• W1992062620 hasConceptScore W1992062620C2779201268 @default.
• W1992062620 hasConceptScore W1992062620C2780570554 @default.
• W1992062620 hasConceptScore W1992062620C2781324293 @default.
• W1992062620 hasConceptScore W1992062620C41183919 @default.
• W1992062620 hasConceptScore W1992062620C538909803 @default.
• W1992062620 hasConceptScore W1992062620C55493867 @default.
• W1992062620 hasConceptScore W1992062620C71240020 @default.
• W1992062620 hasIssue "1" @default.
• W1992062620 hasLocation W19920626201 @default.
• W1992062620 hasLocation W19920626202 @default.
• W1992062620 hasLocation W19920626203 @default.
• W1992062620 hasLocation W19920626204 @default.
• W1992062620 hasOpenAccess W1992062620 @default.
• W1992062620 hasPrimaryLocation W19920626201 @default.
• W1992062620 hasRelatedWork W1002916168 @default.
• W1992062620 hasRelatedWork W1992439512 @default.
• W1992062620 hasRelatedWork W2031260596 @default.
• W1992062620 hasRelatedWork W2050698325 @default.
• W1992062620 hasRelatedWork W2051549153 @default.
• W1992062620 hasRelatedWork W2072227352 @default.
• W1992062620 hasRelatedWork W2084582310 @default.
• W1992062620 hasRelatedWork W2324031045 @default.
• W1992062620 hasRelatedWork W2327598960 @default.
• W1992062620 hasRelatedWork W2943797645 @default.
• W1992062620 hasVolume "20" @default.
• W1992062620 isParatext "false" @default.

• next