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- W1992073116 abstract "Lymphocytic infundibulo-neurohypophysitis (LINH), a rare autoimmune disease, is distinct from lymphocytic hypophysitis and is characterized by lymphocytic and plasma cell infiltration of the posterior lobe of the pituitary and the pituitary stalk. 1 Kojima H. Nojima T. Nagashima K. et al. Diabetes insipidus caused by lymphocytic infundibuloneurohypophysitis. Arch Pathol Lab Med. 1989; 113: 1399-1401 PubMed Google Scholar We report the case of a young boy who presented with recurrent, steroid-responsive optic nerve dysfunction and diabetes insipidus. T1-weighted magnetic resonance imaging scans of the brain showed an isointense soft tissue mass within the sella turcica and a thickened pituitary stalk. Tissue specimen resected at transsphenoidal surgery revealed chronic inflammation with infiltration of lymphocytes and no granulomatosis or necrosis, establishing the diagnosis of LINH. 2 Imura H. Nakao K. Shimatsu A. Ogawa Y. Sando T. Fujisawa I. et al. Lymphocytic infundibulo-neurohypophysitis as a cause of central diabetes insipidus. N Engl J Med. 1993; 329: 683-689 Crossref PubMed Scopus (342) Google Scholar This is the first report of optic neuropathy in association with LINH in a child. Lymphocytic infundibulo-neurohypophysitis (LINH), a rare autoimmune disease, is distinct from lymphocytic hypophysitis and is characterized by lymphocytic and plasma cell infiltration of the posterior lobe of the pituitary and the pituitary stalk. 1 Kojima H. Nojima T. Nagashima K. et al. Diabetes insipidus caused by lymphocytic infundibuloneurohypophysitis. Arch Pathol Lab Med. 1989; 113: 1399-1401 PubMed Google Scholar We report the case of a young boy who presented with recurrent, steroid-responsive optic nerve dysfunction and diabetes insipidus. T1-weighted magnetic resonance imaging scans of the brain showed an isointense soft tissue mass within the sella turcica and a thickened pituitary stalk. Tissue specimen resected at transsphenoidal surgery revealed chronic inflammation with infiltration of lymphocytes and no granulomatosis or necrosis, establishing the diagnosis of LINH. 2 Imura H. Nakao K. Shimatsu A. Ogawa Y. Sando T. Fujisawa I. et al. Lymphocytic infundibulo-neurohypophysitis as a cause of central diabetes insipidus. N Engl J Med. 1993; 329: 683-689 Crossref PubMed Scopus (342) Google Scholar This is the first report of optic neuropathy in association with LINH in a child." @default.
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- W1992073116 date "2009-04-01" @default.
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- W1992073116 title "Lymphocytic infundibulo-neurohypophysitis: An unusual cause of recurrent optic neuropathy in a child" @default.
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