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- W1992073263 abstract "Anxiety disorders are the most common psychiatric disorders. Typical medications used to treat patients are benzodiazepines or antidepressants that target serotonin (5-HT) activity. The ionotropic 5-HT3 receptor has emerged as a potential therapeutic target because selective antagonist compounds reduce anxiety in rodents, primates, and humans. 5-HT binds to the extracellular N-terminus of the 5-HT3A receptor subunit, but receptor activation is also enhanced by distinct allosteric sites. It is not known if specific molecular subunits of the 5-HT3 receptor modulate anxiety. To address this issue, we characterized anxiety-like behavior of mice with a targeted deletion of the 5-HT3A receptor subunit gene in the light/dark box, elevated plus maze, and novelty interaction animal models of anxiety. 5-HT3A null mice exhibited an anxiolytic behavioral phenotype that was highly correlated across behavioral measures. This evidence indicates that the 5-HT3A molecular subunit influences anxiety-like behavior. Pharmacotherapy that targets specifically the 5-HT3A receptor subunit may provide a novel treatment for anxiety disorders." @default.
- W1992073263 created "2016-06-24" @default.
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- W1992073263 date "2003-02-01" @default.
- W1992073263 modified "2023-09-27" @default.
- W1992073263 title "Targeted gene deletion of the 5-HT3A receptor subunit produces an anxiolytic phenotype in mice" @default.
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- W1992073263 doi "https://doi.org/10.1016/s0014-2999(02)02960-6" @default.
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