FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992074467> ?p ?o ?g. }

• W1992074467 endingPage "172" @default.
• W1992074467 startingPage "157" @default.
• W1992074467 abstract "Hyperglycemia-caused imbalances in metabolic pathways as well as microvascular changes in neuron lead to development of diabetic neuropathy. It is the most common long-term complications of diabetes, affecting 50% of the patient worldwide and characterized by clinical symptoms like elevated levels of allodynia and hyperalgesia, reduced nerve conduction velocity, neuronal hypoxia and nerve fibre degeneration. The aim of present investigation was to determine the therapeutic potential of Coenzyme Q10 and its combination with Pyridoxine in streptozotocin (STZ) induced diabetic neuropathic pain. Intraperitoneal administration of STZ to male Sprague Dawley rats (150–200 g) resulted in significant increase in blood glucose level, cholesterol as well as triglyceride concentration, aldose reductase, glycated Hb, neural calcium level along with oxidative–nitrosative stress and it significantly reduced the level of membrane bound inorganic phosphate enzyme, i.e. Na+K+ATPase. These biochemical alterations resulted in a decrease in mechano-tactile allodynia, mechanical hyperalgesia, thermal hyperalgesia, motor nerve conduction velocity along with sensory nerve conduction velocity and thus the development of diabetic neuropathy. Chronic treatment with Coenzyme Q10 (50 and 100 mg/kg) for 4 weeks significantly and dose dependant attenuated (P < 0.05) this elevated levels of blood glucose, cholesterol as well as triglyceride, aldose reductase, glycated Hb, neural calcium along with endogenous enzymes to reduce oxido-nitrosative stress. Thus, it significantly restored (P < 0.05) the level of nociceptive threshold, motor nerve conduction velocity along with sensory nerve conduction velocity and thus improved STZ-induced diabetic neuropathic pain. Major finding of the investigation was the combination of Coenzyme Q10 (100 mg/kg) along with Pyridoxine (100 mg/kg) showed more significant attenuation of the neuropathic pain than Coenzyme Q10 (100 mg/kg) or Pyridoxine (100 mg/kg) alone treated groups. The combination of Coenzyme Q10 and Pyridoxine not only attenuated the hyperglycemia but also showed the significant decrease in neuropathic pain via inhibition of elevated levels of hyperlipidemia, glycated Hb, oxidative–nitrosative stress as well as elevation in the membrane bound inorganic phosphate enzyme that leads to diminution in the allodynia and hyperalgesia." @default.
• W1992074467 created "2016-06-24" @default.
• W1992074467 creator A5000496283 @default.
• W1992074467 creator A5008189563 @default.
• W1992074467 creator A5034653647 @default.
• W1992074467 creator A5043388983 @default.
• W1992074467 creator A5049578983 @default.
• W1992074467 creator A5079134591 @default.
• W1992074467 creator A5083288322 @default.
• W1992074467 creator A5083350984 @default.
• W1992074467 date "2012-10-01" @default.
• W1992074467 modified "2023-09-27" @default.
• W1992074467 title "Elucidation of ameliorative effect of Co-enzyme Q10 in streptozotocin-induced diabetic neuropathic perturbation by modulation of electrophysiological, biochemical and behavioral markers" @default.
• W1992074467 cites W1499478787 @default.
• W1992074467 cites W1640540908 @default.
• W1992074467 cites W166048584 @default.
• W1992074467 cites W1750690213 @default.
• W1992074467 cites W1775749144 @default.
• W1992074467 cites W1837902822 @default.
• W1992074467 cites W1899938340 @default.
• W1992074467 cites W1965026439 @default.
• W1992074467 cites W1965515658 @default.
• W1992074467 cites W1965634002 @default.
• W1992074467 cites W1967702688 @default.
• W1992074467 cites W1970472606 @default.
• W1992074467 cites W1972038155 @default.
• W1992074467 cites W1974560120 @default.
• W1992074467 cites W1976410413 @default.
• W1992074467 cites W1977879939 @default.
• W1992074467 cites W1978695292 @default.
• W1992074467 cites W1981781541 @default.
• W1992074467 cites W1984637736 @default.
• W1992074467 cites W1984829055 @default.
• W1992074467 cites W1988244470 @default.
• W1992074467 cites W1990003005 @default.
• W1992074467 cites W1991053791 @default.
• W1992074467 cites W1994976931 @default.
• W1992074467 cites W1997259202 @default.
• W1992074467 cites W1998361564 @default.
• W1992074467 cites W2009740792 @default.
• W1992074467 cites W2012168857 @default.
• W1992074467 cites W2014007136 @default.
• W1992074467 cites W2014824398 @default.
• W1992074467 cites W2018483249 @default.
• W1992074467 cites W2019732568 @default.
• W1992074467 cites W2020121076 @default.
• W1992074467 cites W2023096054 @default.
• W1992074467 cites W2028232195 @default.
• W1992074467 cites W2028860538 @default.
• W1992074467 cites W2030499160 @default.
• W1992074467 cites W2034856251 @default.
• W1992074467 cites W2035069368 @default.
• W1992074467 cites W2039208701 @default.
• W1992074467 cites W2040843650 @default.
• W1992074467 cites W2044437167 @default.
• W1992074467 cites W2050449551 @default.
• W1992074467 cites W2050629341 @default.
• W1992074467 cites W2050679843 @default.
• W1992074467 cites W2054112040 @default.
• W1992074467 cites W2066796908 @default.
• W1992074467 cites W2069132215 @default.
• W1992074467 cites W2069886558 @default.
• W1992074467 cites W2070869643 @default.
• W1992074467 cites W2075769621 @default.
• W1992074467 cites W2086290261 @default.
• W1992074467 cites W2087259044 @default.
• W1992074467 cites W2087401864 @default.
• W1992074467 cites W2087762082 @default.
• W1992074467 cites W2087868042 @default.
• W1992074467 cites W2088208009 @default.
• W1992074467 cites W2090095746 @default.
• W1992074467 cites W2093206847 @default.
• W1992074467 cites W2093732280 @default.
• W1992074467 cites W2093880773 @default.
• W1992074467 cites W2096535920 @default.
• W1992074467 cites W2097651697 @default.
• W1992074467 cites W2099776063 @default.
• W1992074467 cites W2101979298 @default.
• W1992074467 cites W2104865391 @default.
• W1992074467 cites W2109430885 @default.
• W1992074467 cites W2112374588 @default.
• W1992074467 cites W2114244415 @default.
• W1992074467 cites W2124098523 @default.
• W1992074467 cites W2136331613 @default.
• W1992074467 cites W2137672734 @default.
• W1992074467 cites W2138676765 @default.
• W1992074467 cites W2139823029 @default.
• W1992074467 cites W2149411246 @default.
• W1992074467 cites W2156905192 @default.
• W1992074467 cites W2159614641 @default.
• W1992074467 cites W2160073318 @default.
• W1992074467 cites W2167729710 @default.
• W1992074467 cites W2172201406 @default.
• W1992074467 cites W2183817340 @default.
• W1992074467 cites W2201358839 @default.
• W1992074467 cites W2313945403 @default.
• W1992074467 cites W321991892 @default.
• W1992074467 cites W4238056098 @default.

• next