FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992077904> ?p ?o ?g. }

• W1992077904 endingPage "274" @default.
• W1992077904 startingPage "267" @default.
• W1992077904 abstract "Interferon-γ (IFN-γ) is a cytokine with multiple activities on a variety of cells. Under various circumstances, IFN-γ can exhibit either pro-inflammatory or inhibitory actions. Treatment of SJL/J mice with a monoclonal antibody (Mab) to IFN-γ during the afferent limb of the immune response to myelin protein produced an enhancement of acute experimental allergic encephalomyelitis (EAE), with increased morbidity, mortality and earlier onset of disease. Systemic administration of IFN-γ did not improve or worsen clinical outcome, but delayed disease onset. Passive transfer of immune lymph node cells co-activated with MBP and anti-IFN-γ Mab resulted in more severe disease than that induced by MBP stimulated cells or MBP and IFN-γ co-stimulated cells. However, in vitro proliferation of an MBP specific T cell line was not influenced by IFN-γ nor anti-IFN-γ treatment. Mab to IFN-γ inhibited suppressor function, in a non-specific assay. These in vivo and in vitro results suggest that systemic IFN-γ serves as a physiological regulator of a suppressor mechanism in EAE. The abrogation of this regulatory mechanism by anti-IFN-γ administration contributes to a more severe form of experimental allergic encephalomyelitis." @default.
• W1992077904 created "2016-06-24" @default.
• W1992077904 creator A5005804424 @default.
• W1992077904 creator A5022853456 @default.
• W1992077904 creator A5024583995 @default.
• W1992077904 creator A5025501697 @default.
• W1992077904 creator A5026218728 @default.
• W1992077904 creator A5027075504 @default.
• W1992077904 creator A5038281835 @default.
• W1992077904 creator A5045239840 @default.
• W1992077904 creator A5051908290 @default.
• W1992077904 creator A5055562161 @default.
• W1992077904 date "1993-01-01" @default.
• W1992077904 modified "2023-10-03" @default.
• W1992077904 title "Monoclonal Anti-Gamma Interferon Antibodies Enhance Experimental Allergic Encephalomyelitis" @default.
• W1992077904 cites W1504285588 @default.
• W1992077904 cites W1566483379 @default.
• W1992077904 cites W1873524018 @default.
• W1992077904 cites W1898933516 @default.
• W1992077904 cites W1906640112 @default.
• W1992077904 cites W1932588934 @default.
• W1992077904 cites W1974439206 @default.
• W1992077904 cites W1982093100 @default.
• W1992077904 cites W1982825320 @default.
• W1992077904 cites W2000665475 @default.
• W1992077904 cites W2001979011 @default.
• W1992077904 cites W2009260285 @default.
• W1992077904 cites W2019976074 @default.
• W1992077904 cites W2029736420 @default.
• W1992077904 cites W2048327985 @default.
• W1992077904 cites W2061044306 @default.
• W1992077904 cites W2075464971 @default.
• W1992077904 cites W2080305673 @default.
• W1992077904 cites W2099478515 @default.
• W1992077904 cites W2142177598 @default.
• W1992077904 cites W2160344319 @default.
• W1992077904 doi "https://doi.org/10.3109/08916939309014645" @default.
• W1992077904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7517706" @default.
• W1992077904 hasPublicationYear "1993" @default.
• W1992077904 type Work @default.
• W1992077904 sameAs 1992077904 @default.
• W1992077904 citedByCount "109" @default.
• W1992077904 countsByYear W19920779042012 @default.
• W1992077904 countsByYear W19920779042013 @default.
• W1992077904 countsByYear W19920779042014 @default.
• W1992077904 countsByYear W19920779042015 @default.
• W1992077904 countsByYear W19920779042016 @default.
• W1992077904 countsByYear W19920779042017 @default.
• W1992077904 countsByYear W19920779042018 @default.
• W1992077904 countsByYear W19920779042019 @default.
• W1992077904 countsByYear W19920779042020 @default.
• W1992077904 countsByYear W19920779042021 @default.
• W1992077904 countsByYear W19920779042022 @default.
• W1992077904 countsByYear W19920779042023 @default.
• W1992077904 crossrefType "journal-article" @default.
• W1992077904 hasAuthorship W1992077904A5005804424 @default.
• W1992077904 hasAuthorship W1992077904A5022853456 @default.
• W1992077904 hasAuthorship W1992077904A5024583995 @default.
• W1992077904 hasAuthorship W1992077904A5025501697 @default.
• W1992077904 hasAuthorship W1992077904A5026218728 @default.
• W1992077904 hasAuthorship W1992077904A5027075504 @default.
• W1992077904 hasAuthorship W1992077904A5038281835 @default.
• W1992077904 hasAuthorship W1992077904A5045239840 @default.
• W1992077904 hasAuthorship W1992077904A5051908290 @default.
• W1992077904 hasAuthorship W1992077904A5055562161 @default.
• W1992077904 hasConcept C126322002 @default.
• W1992077904 hasConcept C159654299 @default.
• W1992077904 hasConcept C203014093 @default.
• W1992077904 hasConcept C2776178377 @default.
• W1992077904 hasConcept C2777899865 @default.
• W1992077904 hasConcept C2778486448 @default.
• W1992077904 hasConcept C2778609137 @default.
• W1992077904 hasConcept C2778690821 @default.
• W1992077904 hasConcept C2780640218 @default.
• W1992077904 hasConcept C2780841837 @default.
• W1992077904 hasConcept C2780876595 @default.
• W1992077904 hasConcept C529278444 @default.
• W1992077904 hasConcept C542903549 @default.
• W1992077904 hasConcept C71924100 @default.
• W1992077904 hasConcept C86803240 @default.
• W1992077904 hasConcept C8891405 @default.
• W1992077904 hasConceptScore W1992077904C126322002 @default.
• W1992077904 hasConceptScore W1992077904C159654299 @default.
• W1992077904 hasConceptScore W1992077904C203014093 @default.
• W1992077904 hasConceptScore W1992077904C2776178377 @default.
• W1992077904 hasConceptScore W1992077904C2777899865 @default.
• W1992077904 hasConceptScore W1992077904C2778486448 @default.
• W1992077904 hasConceptScore W1992077904C2778609137 @default.
• W1992077904 hasConceptScore W1992077904C2778690821 @default.
• W1992077904 hasConceptScore W1992077904C2780640218 @default.
• W1992077904 hasConceptScore W1992077904C2780841837 @default.
• W1992077904 hasConceptScore W1992077904C2780876595 @default.
• W1992077904 hasConceptScore W1992077904C529278444 @default.
• W1992077904 hasConceptScore W1992077904C542903549 @default.
• W1992077904 hasConceptScore W1992077904C71924100 @default.
• W1992077904 hasConceptScore W1992077904C86803240 @default.
• W1992077904 hasConceptScore W1992077904C8891405 @default.
• W1992077904 hasIssue "4" @default.

• next