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• W1992078771 abstract "SUMMARY Neutrophil dysfunction in HIV disease is well described. We examined the expression of neutrophil adhesion molecules amongst 72 HIV-infected subjects using a whole blood flow cytometric assay with FITC- and R-PE-labelled isotype-specific MoAbs. We report lesser expression of CD11a (LFA-1) and l-selectin (CD62L) on the circulating neutrophils of HIV+ subjects compared with HIV− controls. Expression of CD11b (Mac-1) was unchanged. Shedding of l-selectin and up-regulation of CD11b in response to in vitro stimulation with N-formyl-methionyl-leucyl-phenylalanine (fMLP) were less in HIV+ compared with HIV− subjects, most markedly in subjects with CD4 cell counts &lt; 100 cells/mm3. These results suggest that neutrophil dysfunction in HIV disease, which increases with disease progression, may be attributable to dysregulated adhesion molecule expression." @default.
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• W1992078771 date "1998-10-01" @default.
• W1992078771 modified "2023-10-10" @default.
• W1992078771 title "Neutrophil adhesion molecules in HIV disease" @default.
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• W1992078771 doi "https://doi.org/10.1046/j.1365-2249.1998.00686.x" @default.
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