Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992078851> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1992078851 endingPage "865" @default.
- W1992078851 startingPage "854" @default.
- W1992078851 abstract "The effects of fibroblast growth factor (FGF) and epidermal growth factor (EGF) on the lifespan of cultured bovine granulosa cell cultures have been investigated. Granulosa cell cultures from small follicles (4-7 mm) had a lifespan of 11-12 generations, whereas the lifespan of cultures originating from large follicles did not exceed seven generations. The addition of either EGF or FGF to the medium of cultures originating from small follicles greatly increased the lifetime of the cultures, which can then exceed 60 generations. A similar, although less pronounced, effect was observed with cultures originating from large follicles. The lifespan of granulosa cell cultures depends upon the presence of FGF or EGF in the medium, as the deletion of the mitogens resulted in rapid terminal differentiation and a shortened replicative lifespan. As either FGF or EGF can prolong the replicative lifespan of granulosa cell cultures, it is suggested that limited replicative lifespan when maintained in the absence of mitogens is not so much determined by a fixed rate of mutation as it is by the culture conditions in which the cells are maintained." @default.
- W1992078851 created "2016-06-24" @default.
- W1992078851 creator A5028378663 @default.
- W1992078851 creator A5082038516 @default.
- W1992078851 date "1978-09-01" @default.
- W1992078851 modified "2023-09-27" @default.
- W1992078851 title "The Effects of the Epidermal and Fibroblast Growth Factors on the Replicative Lifespan of Cultured Bovine Granulosa Cells*" @default.
- W1992078851 cites W1498071142 @default.
- W1992078851 cites W171373504 @default.
- W1992078851 cites W1989621236 @default.
- W1992078851 cites W1990808637 @default.
- W1992078851 cites W2004314923 @default.
- W1992078851 cites W2047194677 @default.
- W1992078851 cites W2098648941 @default.
- W1992078851 cites W2167559072 @default.
- W1992078851 cites W2277640232 @default.
- W1992078851 cites W2347185425 @default.
- W1992078851 cites W2746604719 @default.
- W1992078851 cites W969821870 @default.
- W1992078851 doi "https://doi.org/10.1210/endo-103-3-854" @default.
- W1992078851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/311281" @default.
- W1992078851 hasPublicationYear "1978" @default.
- W1992078851 type Work @default.
- W1992078851 sameAs 1992078851 @default.
- W1992078851 citedByCount "73" @default.
- W1992078851 countsByYear W19920788512013 @default.
- W1992078851 countsByYear W19920788512014 @default.
- W1992078851 countsByYear W19920788512021 @default.
- W1992078851 crossrefType "journal-article" @default.
- W1992078851 hasAuthorship W1992078851A5028378663 @default.
- W1992078851 hasAuthorship W1992078851A5082038516 @default.
- W1992078851 hasConcept C126322002 @default.
- W1992078851 hasConcept C134018914 @default.
- W1992078851 hasConcept C16685009 @default.
- W1992078851 hasConcept C170493617 @default.
- W1992078851 hasConcept C202751555 @default.
- W1992078851 hasConcept C2776362946 @default.
- W1992078851 hasConcept C2777203538 @default.
- W1992078851 hasConcept C2778324911 @default.
- W1992078851 hasConcept C2780381497 @default.
- W1992078851 hasConcept C54355233 @default.
- W1992078851 hasConcept C62112901 @default.
- W1992078851 hasConcept C64241487 @default.
- W1992078851 hasConcept C71924100 @default.
- W1992078851 hasConcept C74373430 @default.
- W1992078851 hasConcept C81885089 @default.
- W1992078851 hasConcept C86803240 @default.
- W1992078851 hasConcept C95444343 @default.
- W1992078851 hasConceptScore W1992078851C126322002 @default.
- W1992078851 hasConceptScore W1992078851C134018914 @default.
- W1992078851 hasConceptScore W1992078851C16685009 @default.
- W1992078851 hasConceptScore W1992078851C170493617 @default.
- W1992078851 hasConceptScore W1992078851C202751555 @default.
- W1992078851 hasConceptScore W1992078851C2776362946 @default.
- W1992078851 hasConceptScore W1992078851C2777203538 @default.
- W1992078851 hasConceptScore W1992078851C2778324911 @default.
- W1992078851 hasConceptScore W1992078851C2780381497 @default.
- W1992078851 hasConceptScore W1992078851C54355233 @default.
- W1992078851 hasConceptScore W1992078851C62112901 @default.
- W1992078851 hasConceptScore W1992078851C64241487 @default.
- W1992078851 hasConceptScore W1992078851C71924100 @default.
- W1992078851 hasConceptScore W1992078851C74373430 @default.
- W1992078851 hasConceptScore W1992078851C81885089 @default.
- W1992078851 hasConceptScore W1992078851C86803240 @default.
- W1992078851 hasConceptScore W1992078851C95444343 @default.
- W1992078851 hasIssue "3" @default.
- W1992078851 hasLocation W19920788511 @default.
- W1992078851 hasLocation W19920788512 @default.
- W1992078851 hasOpenAccess W1992078851 @default.
- W1992078851 hasPrimaryLocation W19920788511 @default.
- W1992078851 hasRelatedWork W182207217 @default.
- W1992078851 hasRelatedWork W1873784329 @default.
- W1992078851 hasRelatedWork W2014964929 @default.
- W1992078851 hasRelatedWork W2032591328 @default.
- W1992078851 hasRelatedWork W2066663472 @default.
- W1992078851 hasRelatedWork W2079251901 @default.
- W1992078851 hasRelatedWork W2083584330 @default.
- W1992078851 hasRelatedWork W2089465640 @default.
- W1992078851 hasRelatedWork W2151370338 @default.
- W1992078851 hasRelatedWork W2410818128 @default.
- W1992078851 hasVolume "103" @default.
- W1992078851 isParatext "false" @default.
- W1992078851 isRetracted "false" @default.
- W1992078851 magId "1992078851" @default.
- W1992078851 workType "article" @default.