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• W1992083221 abstract "A current interest in radiobiology is the investigation of shifts in the distribution of oxygen tension in solid tumors during the course of fractionated radiation therapy. If upward shifts in oxygen tension occur, the radiobiological significance of a small focus of hypoxic cells in the untreated tumor could be drastically reduced. Examinations for such shifts in pO2 distributions within tumor tissue in man have been based on the polarographic technic with use of very small electrodes, i.e., ≈50–100 µ in diameter. Results have been reported from three laboratories, however, and they have not been consistent (1–3). In contrast to these equivocal results from Polarographic studies at the clinical level, experimental data from three laboratories strongly indicate that during fractionated irradiation there is an improved oxygenation of tumor tissue (4–8). First, studies of a mouse mammary carcinoma showed that an appreciably larger fraction of cells responded as though they were aerobic when radiation was administered in ten equal doses than when a single dose was given (4). Similar findings were obtained in studies of a squamous-cell carcinoma and a fibrosarcoma (5). Van Putten and Kallman (6) investigated a C3H mouse fibrosarcoma and found that during the course of fractionated irradiation (200 R daily × 5), the hypoxic cell population decreased much more rapidly than expected, indicating a shift of pO2 tensions during the five-day treatment. Similarly, Thomlinson (7) analyzed the changes in the growth curves of a benzpyrene-induced fibrosarcoma (transplanted into inbred rats). He employed one and two doses of radiation administered under conditions of hypoxia, air, or respiration of oxygen at high pressure. Results were interpreted as showing that following a dose of radiation there is a very rapid increase in tumor tissue pO2. In addition, microradiographic studies on rat tumors before and after irradiation were interpreted by Rubin (9) as indicating a decrease in intercapillary distances following irradiation. The present report describes an experiment which was planned to estimate the extent of transfer of cells out of the hypoxic compartment during the first five days following a single radiation dose to a mouse mammary carcinoma. Materials and Methods Animal Tumor System: These experiments were performed on third generation transplants from a single C3H/He mouse mammary carcinoma. A previous report (10) presented details of: origin and maintenance of this tumor; technic of preparation of suspension of tumor cells; counting of viable cells. For these experiments an inoculum of 5–10 µl containing 105 viable tumor cells was injected into the muscle mass of the distal right thigh. Experimental Animals: As recipients of the tumor transplantation we used (C3H/He × C57)F1 hybrid mice, designated hereafter as C3BF1, obtained from the Texas Inbred Mouse Company, Houston, Texas." @default.
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• W1992083221 date "1968-02-01" @default.
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• W1992083221 title "Effect of a Single Dose of Radiation on Proportion of Hypoxic Cells in a C3H Mouse Mammary Carcinoma" @default.
• W1992083221 doi "https://doi.org/10.1148/90.2.325" @default.
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