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• W1992093536 abstract "The N-methyl-D-aspartate (NMDA) receptor has been implicated as a putative sight of action for acamprosate, a novel drug that reduces craving for alcohol. The purpose of this study was to assess the effect of acamprosate on the function of native NMDA receptors expressed in primary cultured striatal and cerebellar granule cells, as well as ethanol inhibition and spermine modulation of these receptors, using whole-cell patch-clamp electrophysiological techniques. Under all circumstances, acamprosate (0.1-300 microM) did not alter NMDA- or glutamate-induced currents. Acamprosate did not alter the inhibitory effects of ethanol (10-100 mM) on receptor function. In a subpopulation of striatal neurons, acamprosate did reverse the potentiating effects of spermine. These findings indicate that although acamprosate may modify polyamine modulation of the NMDA receptor, acamprosate alone does not alter receptor function nor does it modify ethanol inhibition of this receptor expressed in primary cultured striatal and cerebellar granule neurons." @default.
• W1992093536 created "2016-06-24" @default.
• W1992093536 creator A5036461897 @default.
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• W1992093536 date "2000-04-01" @default.
• W1992093536 modified "2023-10-11" @default.
• W1992093536 title "Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons" @default.
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• W1992093536 doi "https://doi.org/10.1016/s0014-2999(00)00195-3" @default.
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