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- W1992095159 abstract "Diabetes Mellitus (DM) causes damage in multiple organs and the vessels due to the metabolic state of hyperglycemia and insulin resistance. Increased arterial stiffness may be an important pathway linking DM to the increased cardiovascular (CV) risk by mechanisms of increased cardiac afterload, augmentation of pulse pressure, a subsequent transmission of high pulsatile flow to the end organs and furthermore as a representative of arteriosclerosis. Magnetic Resonance (MR) assessment of aortic pulse wave velocity (PWV) offers a good reproducible non-invasive tool for the detection of arterial stiffness. Furthermore MRI is an accurate tool for the detection of cardiac dysfunction and vascular cerebral lesions, like white matter hyperintensities (WMHs). To our knowledge, MRI has not previously been used to simultaneously determine end organ damage in the aorta, heart and the brain in patients with DM. We hypothesize that there is an important role for DM induced aortic stiffness in the underlying mechanism of cardiac failure and cerebral white matter hyperintensities in DM patients." @default.
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- W1992095159 date "2009-01-01" @default.
- W1992095159 modified "2023-09-23" @default.
- W1992095159 title "Aortic stiffness as an independent predictor of cardiac function and cerebral white matter hyperintensities in diabetes mellitus assessed by Magnetic Resonance Imaging" @default.
- W1992095159 doi "https://doi.org/10.1186/1532-429x-11-s1-p169" @default.
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