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- W1992097410 abstract "Interference with cell proliferation during central nervous system development has been shown to have permanent effects on both anatomy and behavior. Treatment with 5-azacytidine on the 16th day of embryonic life leads to behavioral abnormalities usually associated with hippocampal damage. Treatment on embryonic day 18 also leads to some functional changes characteristic of animals with hippocampal lesions, but not the same ones seen after the earlier treatment. Anatomically, both groups were “small for date” and remained significantly smaller than controls throughout life. Brain weight was significantly reduced after treatment on the 16th day of gestation but not on the 18th. Labeling with [3H]thymidine at the same stages indicated that neurons for several central nervous system structures are produced on those treatment days. Histological measurements of those structures in azacytidine-treated animals revealed significant reductions in frontal cortex, lateral septum, pyramidal cell layer of hippocampus, dentate gyrus, and width of hippocampus, and whole brain in animals treated on embryonic day 16. The later treatment reduced only the lateral septum, dentate gyrus, and width of whole brain. In the earlier treatment group, the anatomy of animals with aberrant behavior was compared with the anatomy of animals which behaved more like controls. Within the treatment group, brain weight, body weight, and size of CA3 and CA4 of the pyramidal cell layer were significantly correlated with abnormal behavior. The results emphasize the close relationship between the extent and location of cell loss and the behavioral effects of prenatally induced brain damage." @default.
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- W1992097410 title "Morphological correlates of behavioral abnormalities in experimental congenital brain damage" @default.
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- W1992097410 doi "https://doi.org/10.1016/0014-4886(77)90046-2" @default.
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