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- W1992101443 abstract "Synthetic α-hANP was infused into 8 normotensive, euvolemic volunteers to examine the effects on plasma and urinary cyclic-GMP. The dose given and duratiol. of α-hANP (0.1 μg/kg/min, 20 min) led to the significant diuresis, saliuresis and hypotensive effects in each subject. The mean plasma cyclic-GMP concentration was clearly elevated at 5 min after infusion and attained 8 fold of the mean basal concentrations by the end of infusion. The mean urinary cyclic-GMP excretion rate also showed 3.5 fold increases of the basal excretion rate with synthetic α-hANP administration (before loading: 0.69 ± 0.22 p moles/g creat., after loading: 2.85 ± 0.28 p moles/g creat.). However, there was no apparent change on plasma or urinary cyclic-AMP during the infusion. The result clearly demonstrated that synthetic α-hANP selectively induces the cyclic-GMP in concomitant with the marked diuretic, natriuretic and hypotensive effects in human subjects." @default.
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- W1992101443 date "1986-01-01" @default.
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- W1992101443 title "α-Human Atrial Natriuretic Polypeptide-Induced Rise of Plasma and Urinary Cyclic 3″5″-Guanosine Monophosphate Concentration in Human Subjects" @default.
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- W1992101443 doi "https://doi.org/10.3109/10641968609074764" @default.
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