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• W1992106970 abstract "Dedifferentiated chondrosarcomas are cartilaginous tumors that consist of two distinguishable components, a lowgrade chondrosarcoma (chondrogenic) component and a highgrade dedifferentiated (anaplastic) component. The tumor cells in both components seem to originate from a single precursor, but there are a substantial number of genetic alterations in the anaplastic component. The underlying mechanism of dedifferentiation is unknown, but cell cycle regulators p16, p53 and retinoblastoma appear to have important roles in tumor development and dedifferentiation. In this article, molecular pathogenesis of dedifferentiated chondrosarcomas is reviewed." @default.
• W1992106970 created "2016-06-24" @default.
• W1992106970 creator A5091460629 @default.
• W1992106970 date "2014-06-01" @default.
• W1992106970 modified "2023-09-24" @default.
• W1992106970 title "The molecular pathogenesis of dedifferentiated chondrosarcoma" @default.
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• W1992106970 doi "https://doi.org/10.4103/0019-5413.132506" @default.
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