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- W1992118894 abstract "Genetic and environmental factors interact to regulate body weight. Overall, the heritability of obesity is estimated at 40% to 70%. More than 244 genes have been found to strongly affect adiposity when overexpressed or deleted in mice. These genes can be considered in four broad categories: regulation of food intake by molecular signalling in the hypothalamus and hindbrain by signals originating in adipose tissue, gut and other organs; regulation of adipocyte differentiation and fat storage; regulation of spontaneous exercise activity; and effect on basal and postprandial thermogenesis. Rare variants in the coding sequences of major candidate genes account for an obese phenotype in 5% to 10% of individuals." @default.
- W1992118894 created "2016-06-24" @default.
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- W1992118894 date "2007-08-01" @default.
- W1992118894 modified "2023-09-27" @default.
- W1992118894 title "Genetic contributors to obesity" @default.
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- W1992118894 doi "https://doi.org/10.1016/s0828-282x(07)71002-4" @default.
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