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- W1992119951 abstract "The hypothesis that cancer is driven by a subpopulation of tumor-initiating or cancer stem cells (CSC), defined by their selective ability for extensive self-renewal and capacity to give rise to nontumorigenic cancer cell progeny through differentiation, has been validated experimentally in diverse human malignancies. Translational relevance of the CSC hypothesis is underlined by emerging novel strategies designed to target all subpopulations within a given tumor in order to effect cancer eradication and improve patient outcomes. Colorectal cancer stem cells (CRSCs) have been identified and successfully isolated by several research groups based on distinct cell-surface marker characteristics. Identification of CRSC populations has led to a wave of discoveries describing novel self-renewal and drug resistance mechanisms in colorectal cancer that represent novel future therapeutic targets. In this review, we will discuss emerging CRSC-specific pathways and the therapeutic promise of targeting this cancer population in colorectal cancer patients." @default.
- W1992119951 created "2016-06-24" @default.
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- W1992119951 creator A5089843842 @default.
- W1992119951 date "2011-03-24" @default.
- W1992119951 modified "2023-09-30" @default.
- W1992119951 title "Colorectal Cancer Stem Cells: Biology and Therapeutic Implications" @default.
- W1992119951 cites W1517748724 @default.
- W1992119951 cites W1966447268 @default.
- W1992119951 cites W1967137553 @default.
- W1992119951 cites W1975993620 @default.
- W1992119951 cites W1979094948 @default.
- W1992119951 cites W1980415581 @default.
- W1992119951 cites W1982603620 @default.
- W1992119951 cites W1983961550 @default.
- W1992119951 cites W1990589849 @default.
- W1992119951 cites W1990757263 @default.
- W1992119951 cites W1991748394 @default.
- W1992119951 cites W1995060691 @default.
- W1992119951 cites W2001544973 @default.
- W1992119951 cites W2002114387 @default.
- W1992119951 cites W2002282481 @default.
- W1992119951 cites W2006239354 @default.
- W1992119951 cites W2006434892 @default.
- W1992119951 cites W2006765115 @default.
- W1992119951 cites W2009886857 @default.
- W1992119951 cites W2011016280 @default.
- W1992119951 cites W2015557036 @default.
- W1992119951 cites W2023377449 @default.
- W1992119951 cites W2023427658 @default.
- W1992119951 cites W2026379260 @default.
- W1992119951 cites W2029231546 @default.
- W1992119951 cites W2034916462 @default.
- W1992119951 cites W2035192365 @default.
- W1992119951 cites W2037632318 @default.
- W1992119951 cites W2042082068 @default.
- W1992119951 cites W2043103956 @default.
- W1992119951 cites W2043746859 @default.
- W1992119951 cites W2049772927 @default.
- W1992119951 cites W2051055358 @default.
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- W1992119951 cites W2062130037 @default.
- W1992119951 cites W2064026242 @default.
- W1992119951 cites W2070698537 @default.
- W1992119951 cites W2081447858 @default.
- W1992119951 cites W2084745919 @default.
- W1992119951 cites W2085581448 @default.
- W1992119951 cites W2088230889 @default.
- W1992119951 cites W2088629757 @default.
- W1992119951 cites W2090562908 @default.
- W1992119951 cites W2090982381 @default.
- W1992119951 cites W2091723114 @default.
- W1992119951 cites W2092691551 @default.
- W1992119951 cites W2092787533 @default.
- W1992119951 cites W2094532696 @default.
- W1992119951 cites W2095692554 @default.
- W1992119951 cites W2097308038 @default.
- W1992119951 cites W2102085111 @default.
- W1992119951 cites W2110310689 @default.
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- W1992119951 cites W2122412604 @default.
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- W1992119951 cites W2125526974 @default.
- W1992119951 cites W2129644533 @default.
- W1992119951 cites W2134427060 @default.
- W1992119951 cites W2137573098 @default.
- W1992119951 cites W2138747235 @default.
- W1992119951 cites W2139458634 @default.
- W1992119951 cites W2142564546 @default.
- W1992119951 cites W2147650118 @default.
- W1992119951 cites W2148858609 @default.
- W1992119951 cites W2149954427 @default.
- W1992119951 cites W2151386025 @default.
- W1992119951 cites W2156149964 @default.
- W1992119951 cites W2156381851 @default.
- W1992119951 cites W2171507631 @default.
- W1992119951 cites W4236891330 @default.
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- W1992119951 doi "https://doi.org/10.1007/s11888-011-0093-2" @default.
- W1992119951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3087297" @default.
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