FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992123148> ?p ?o ?g. }

• W1992123148 endingPage "2152" @default.
• W1992123148 startingPage "2137" @default.
• W1992123148 abstract "Consistent daily rhythms are important to healthy aging according to studies linking disrupted circadian rhythms with negative health impacts. We studied the effects of age and exercise on baseline circadian rhythms and on the circadian system's ability to respond to the perturbation induced by an 8 h advance of the light:dark (LD) cycle as a test of the system's robustness. Mice (male, mPer2luc/C57BL/6) were studied at one of two ages: 3.5 months (n = 39) and >18 months (n = 72). We examined activity records of these mice under entrained and shifted conditions as well as mPER2::LUC measures ex vivo to assess circadian function in the suprachiasmatic nuclei (SCN) and important target organs. Age was associated with reduced running wheel use, fragmentation of activity, and slowed resetting in both behavioral and molecular measures. Furthermore, we observed that for aged mice, the presence of a running wheel altered the amplitude of the spontaneous firing rate rhythm in the SCN in vitro. Following a shift of the LD cycle, both young and aged mice showed a change in rhythmicity properties of the mPER2::LUC oscillation of the SCN in vitro, and aged mice exhibited longer lasting internal desynchrony. Access to a running wheel alleviated some age-related changes in the circadian system. In an additional experiment, we replicated the effect of the running wheel, comparing behavioral and in vitro results from aged mice housed with or without a running wheel (>21 months, n = 8 per group, all examined 4 days after the shift). The impact of voluntary exercise on circadian rhythm properties in an aged animal is a novel finding and has implications for the health of older people living with environmentally induced circadian disruption." @default.
• W1992123148 created "2016-06-24" @default.
• W1992123148 creator A5010343736 @default.
• W1992123148 creator A5011827857 @default.
• W1992123148 creator A5023598330 @default.
• W1992123148 creator A5028653468 @default.
• W1992123148 creator A5039019854 @default.
• W1992123148 creator A5051953985 @default.
• W1992123148 creator A5054396104 @default.
• W1992123148 creator A5063595755 @default.
• W1992123148 date "2013-01-23" @default.
• W1992123148 modified "2023-10-18" @default.
• W1992123148 title "Voluntary exercise can strengthen the circadian system in aged mice" @default.
• W1992123148 cites W1497737563 @default.
• W1992123148 cites W1503365659 @default.
• W1992123148 cites W1566981583 @default.
• W1992123148 cites W1715752662 @default.
• W1992123148 cites W1897507705 @default.
• W1992123148 cites W1966285890 @default.
• W1992123148 cites W1969904423 @default.
• W1992123148 cites W1973056324 @default.
• W1992123148 cites W1978116704 @default.
• W1992123148 cites W1981579010 @default.
• W1992123148 cites W1982781913 @default.
• W1992123148 cites W1983157224 @default.
• W1992123148 cites W1989883159 @default.
• W1992123148 cites W1996441070 @default.
• W1992123148 cites W2002692485 @default.
• W1992123148 cites W2010746789 @default.
• W1992123148 cites W2011065426 @default.
• W1992123148 cites W2011460555 @default.
• W1992123148 cites W2014313900 @default.
• W1992123148 cites W2021731355 @default.
• W1992123148 cites W2033565755 @default.
• W1992123148 cites W2034606510 @default.
• W1992123148 cites W2035077732 @default.
• W1992123148 cites W2035809873 @default.
• W1992123148 cites W2043888433 @default.
• W1992123148 cites W2044522987 @default.
• W1992123148 cites W2051353620 @default.
• W1992123148 cites W2051483750 @default.
• W1992123148 cites W2057080091 @default.
• W1992123148 cites W2057321407 @default.
• W1992123148 cites W2059438747 @default.
• W1992123148 cites W2061105741 @default.
• W1992123148 cites W2065793289 @default.
• W1992123148 cites W2072179768 @default.
• W1992123148 cites W2077038726 @default.
• W1992123148 cites W2077627314 @default.
• W1992123148 cites W2077676121 @default.
• W1992123148 cites W2078978479 @default.
• W1992123148 cites W2080581118 @default.
• W1992123148 cites W2086340552 @default.
• W1992123148 cites W2089650868 @default.
• W1992123148 cites W2091263728 @default.
• W1992123148 cites W2092521700 @default.
• W1992123148 cites W2094874423 @default.
• W1992123148 cites W2103288154 @default.
• W1992123148 cites W2107501611 @default.
• W1992123148 cites W2116475423 @default.
• W1992123148 cites W2116852067 @default.
• W1992123148 cites W2117583882 @default.
• W1992123148 cites W2118976591 @default.
• W1992123148 cites W2127617657 @default.
• W1992123148 cites W2127985481 @default.
• W1992123148 cites W2139372275 @default.
• W1992123148 cites W2140832481 @default.
• W1992123148 cites W2145407434 @default.
• W1992123148 cites W2146586614 @default.
• W1992123148 cites W2149665977 @default.
• W1992123148 cites W2153442479 @default.
• W1992123148 cites W2162712078 @default.
• W1992123148 cites W2164617868 @default.
• W1992123148 cites W2167647692 @default.
• W1992123148 cites W2268659691 @default.
• W1992123148 cites W2463250259 @default.
• W1992123148 cites W4291113428 @default.
• W1992123148 cites W4297924881 @default.
• W1992123148 doi "https://doi.org/10.1007/s11357-012-9502-y" @default.
• W1992123148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3825002" @default.
• W1992123148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23340916" @default.
• W1992123148 hasPublicationYear "2013" @default.
• W1992123148 type Work @default.
• W1992123148 sameAs 1992123148 @default.
• W1992123148 citedByCount "63" @default.
• W1992123148 countsByYear W19921231482013 @default.
• W1992123148 countsByYear W19921231482014 @default.
• W1992123148 countsByYear W19921231482015 @default.
• W1992123148 countsByYear W19921231482016 @default.
• W1992123148 countsByYear W19921231482017 @default.
• W1992123148 countsByYear W19921231482018 @default.
• W1992123148 countsByYear W19921231482019 @default.
• W1992123148 countsByYear W19921231482020 @default.
• W1992123148 countsByYear W19921231482021 @default.
• W1992123148 countsByYear W19921231482022 @default.
• W1992123148 countsByYear W19921231482023 @default.
• W1992123148 crossrefType "journal-article" @default.
• W1992123148 hasAuthorship W1992123148A5010343736 @default.

• next