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- W1992127522 abstract "A new apparatus for simultaneously exposing up to 88 rodents to radioactive aerosols for periods up to 1 hr is described. The animals are held in the apparatus in specially designed tubes with a small hole at the head end and aerosol passes through a small hole in front of each animal's head so that primarily the nasal area of each animal is continuously exposed to a fresh supply of the radioactive aerosol. Provision is made for aerosol generation, for heat treatment of the aerosol, if necessary, and for sampling for aerosol characterization with a cascade impactor, a filter and an electrostatic precipitator. Tests of the operating characteristics of the apparatus performed with nonradioactive aerosols of uranine showed relative consistency of the air concentrations and particle size distributions of aerosol at the exposure ports and at the sampling port. Test exposures of Syrian hamsters to both monodisperse and polydisperse aerosols of fused clay particles labeled with 137Cs yielded satisfactorily uniform average whole body burdens and average lung burdens for animals in each tier of exposure ports in the apparatus. Individual variability of deposition among animals was within the expected range with a coefficient of variation of about 25% for the lung burdens." @default.
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- W1992127522 date "1973-10-01" @default.
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- W1992127522 title "An improved apparatus for acute inhalation exposure of rodents to radioactive aerosols" @default.
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- W1992127522 doi "https://doi.org/10.1016/0041-008x(73)90261-5" @default.
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