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- W1992129110 abstract "G-quadruplexes (G4) are highly stable tetra-stranded secondary DNA structures known to mediate gene regulation. These structures are resolved by DNA helicases and are believed to be a causal factor in the phenotype of premature ageing disorders following mutations in DNA helicase genes. The relevance of G4 structures in ageing may be further implicated by their dynamic relationship with DNA modification mechanisms. When DNA methylation and oxidation occur at the vicinity of G4 elements, they can affect the stability of G4 structures which may in turn mediate gene expression resulting in deleterious effects on genome integrity. Therefore, the influence of nutritional deficiencies or excess on oxidation and methylation mechanisms may be contributing factors affecting the stability of G4 structures and their balance in the human genome. We propose that dietary nutrients such as folate and antioxidants may play a beneficial role in reducing G4-induced DNA damage through changes in G4 structure stability. The current knowledge advocates the importance of resolving G4 structures by DNA helicases for sustained genome integrity, and the existence of stability changes in G4 structures when associated with DNA methylation and oxidation modifications." @default.
- W1992129110 created "2016-06-24" @default.
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- W1992129110 creator A5088218042 @default.
- W1992129110 date "2015-04-01" @default.
- W1992129110 modified "2023-10-18" @default.
- W1992129110 title "G-quadruplexes: A possible epigenetic target for nutrition" @default.
- W1992129110 cites W1482755943 @default.
- W1992129110 cites W1572421661 @default.
- W1992129110 cites W1589421810 @default.
- W1992129110 cites W1810809543 @default.
- W1992129110 cites W1831033366 @default.
- W1992129110 cites W1946213733 @default.
- W1992129110 cites W1964881063 @default.
- W1992129110 cites W1967226250 @default.
- W1992129110 cites W1967636663 @default.
- W1992129110 cites W1969039627 @default.
- W1992129110 cites W1970963988 @default.
- W1992129110 cites W1979369962 @default.
- W1992129110 cites W1982991278 @default.
- W1992129110 cites W1983127291 @default.
- W1992129110 cites W1985038384 @default.
- W1992129110 cites W1988525857 @default.
- W1992129110 cites W1991616035 @default.
- W1992129110 cites W1992223960 @default.
- W1992129110 cites W1996368650 @default.
- W1992129110 cites W1996791589 @default.
- W1992129110 cites W1997415420 @default.
- W1992129110 cites W1997866877 @default.
- W1992129110 cites W1998221055 @default.
- W1992129110 cites W1999472367 @default.
- W1992129110 cites W2002675613 @default.
- W1992129110 cites W2004078197 @default.
- W1992129110 cites W2007992109 @default.
- W1992129110 cites W2010583480 @default.
- W1992129110 cites W2016932385 @default.
- W1992129110 cites W2017983775 @default.
- W1992129110 cites W2019058450 @default.
- W1992129110 cites W2021191052 @default.
- W1992129110 cites W2024910055 @default.
- W1992129110 cites W2031454321 @default.
- W1992129110 cites W2042374693 @default.
- W1992129110 cites W2043841668 @default.
- W1992129110 cites W2048650794 @default.
- W1992129110 cites W2049472183 @default.
- W1992129110 cites W2050913592 @default.
- W1992129110 cites W2056201880 @default.
- W1992129110 cites W2057808601 @default.
- W1992129110 cites W2059116023 @default.
- W1992129110 cites W2065016714 @default.
- W1992129110 cites W2066232199 @default.
- W1992129110 cites W2073722866 @default.
- W1992129110 cites W2074477488 @default.
- W1992129110 cites W2077341010 @default.
- W1992129110 cites W2078411081 @default.
- W1992129110 cites W2080487903 @default.
- W1992129110 cites W2091024619 @default.
- W1992129110 cites W2091482008 @default.
- W1992129110 cites W2091658446 @default.
- W1992129110 cites W2095370504 @default.
- W1992129110 cites W2097364189 @default.
- W1992129110 cites W2097706483 @default.
- W1992129110 cites W2106447785 @default.
- W1992129110 cites W2107754111 @default.
- W1992129110 cites W2108763751 @default.
- W1992129110 cites W2112345478 @default.
- W1992129110 cites W2117517043 @default.
- W1992129110 cites W2118017964 @default.
- W1992129110 cites W2123032740 @default.
- W1992129110 cites W2124007239 @default.
- W1992129110 cites W2132330620 @default.
- W1992129110 cites W2148525284 @default.
- W1992129110 cites W2149047619 @default.
- W1992129110 cites W2149489809 @default.
- W1992129110 cites W2149517538 @default.
- W1992129110 cites W2151888603 @default.
- W1992129110 cites W2152618829 @default.
- W1992129110 cites W2152839556 @default.
- W1992129110 cites W2153879694 @default.
- W1992129110 cites W2155773930 @default.
- W1992129110 cites W2157461349 @default.
- W1992129110 cites W2159310233 @default.
- W1992129110 cites W2170546016 @default.
- W1992129110 cites W2414384071 @default.
- W1992129110 cites W4238141024 @default.
- W1992129110 doi "https://doi.org/10.1016/j.mrrev.2015.03.003" @default.
- W1992129110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26041269" @default.
- W1992129110 hasPublicationYear "2015" @default.
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