FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992132080> ?p ?o ?g. }

• W1992132080 endingPage "210" @default.
• W1992132080 startingPage "202" @default.
• W1992132080 abstract "Propanil, 3,4-dichloropropionanilide, a commonly used herbicide, has been shown to induce effects on the mouse immune system. The aim of this study was to assess the immunotoxicity of propanil in occupationally exposed agricultural workers and to characterize its molecular mechanism of action. Seven agricultural workers intermittently exposed to propanil and 7 healthy matched controls entered the study. Data were collected through physical examination, and laboratory investigations addressed at the main serum, cellular, and functional immune parameters. The levels of exposure were assessed by determining the urine concentration of the major propanil metabolite, 3,4-dichloroaniline. The investigation of serum, cellular, and functional immune parameters suggested that propanil exposure results in a modest immunomodulatory effect, characterized by an increase in the plasma level of IgG1 and in LPS-induced IL-6 release and, by a reduction in PHA-induced IL-10 and IFN release, associated with a reduced IFN/IL-4 ratio. As observed, following in vivo exposure, in vitro treatment of human peripheral blood leukocytes with propanil resulted in a dose-dependent reduction in PHA-induced IFN-gamma and IL-10 production, while LPS-induced TNF-α production was not affected indicating a direct effect of propanil on selected immune parameters. We demonstrated that propanil interfering with PHA-induced intracellular calcium increase modulated IL-10 and IFN-gamma transcription and translation, which indicates that propanil acts on early events triggered by PHA. Overall, our results suggest that human exposure to propanil has slight immunomodulatory effects, and point out that the inhibition of the PHA-induced intracellular calcium rise is an important target of propanil. These findings improve our understanding of the mechanism underlying propanil-induced immunotoxicity." @default.
• W1992132080 created "2016-06-24" @default.
• W1992132080 creator A5000166842 @default.
• W1992132080 creator A5001354290 @default.
• W1992132080 creator A5006329090 @default.
• W1992132080 creator A5006544711 @default.
• W1992132080 creator A5037997257 @default.
• W1992132080 creator A5051874658 @default.
• W1992132080 creator A5053105437 @default.
• W1992132080 creator A5063639436 @default.
• W1992132080 creator A5071080155 @default.
• W1992132080 creator A5082724673 @default.
• W1992132080 date "2007-07-15" @default.
• W1992132080 modified "2023-10-18" @default.
• W1992132080 title "Immunomodulatory effects of the herbicide propanil on cytokine production in humans: In vivo and in vitro exposure" @default.
• W1992132080 cites W1480721056 @default.
• W1992132080 cites W1528276334 @default.
• W1992132080 cites W1573757148 @default.
• W1992132080 cites W1670429687 @default.
• W1992132080 cites W1975814649 @default.
• W1992132080 cites W1989963247 @default.
• W1992132080 cites W2013649034 @default.
• W1992132080 cites W2018329682 @default.
• W1992132080 cites W2031352861 @default.
• W1992132080 cites W2032179694 @default.
• W1992132080 cites W2040029381 @default.
• W1992132080 cites W2040395523 @default.
• W1992132080 cites W2064082146 @default.
• W1992132080 cites W2081335476 @default.
• W1992132080 cites W2108847967 @default.
• W1992132080 cites W2124390644 @default.
• W1992132080 cites W2127669508 @default.
• W1992132080 cites W2141260882 @default.
• W1992132080 cites W2146062046 @default.
• W1992132080 cites W2152770404 @default.
• W1992132080 cites W2165210540 @default.
• W1992132080 cites W2171197061 @default.
• W1992132080 cites W2172678826 @default.
• W1992132080 doi "https://doi.org/10.1016/j.taap.2007.04.017" @default.
• W1992132080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17585980" @default.
• W1992132080 hasPublicationYear "2007" @default.
• W1992132080 type Work @default.
• W1992132080 sameAs 1992132080 @default.
• W1992132080 citedByCount "31" @default.
• W1992132080 countsByYear W19921320802012 @default.
• W1992132080 countsByYear W19921320802013 @default.
• W1992132080 countsByYear W19921320802014 @default.
• W1992132080 countsByYear W19921320802015 @default.
• W1992132080 countsByYear W19921320802016 @default.
• W1992132080 countsByYear W19921320802017 @default.
• W1992132080 countsByYear W19921320802018 @default.
• W1992132080 countsByYear W19921320802021 @default.
• W1992132080 crossrefType "journal-article" @default.
• W1992132080 hasAuthorship W1992132080A5000166842 @default.
• W1992132080 hasAuthorship W1992132080A5001354290 @default.
• W1992132080 hasAuthorship W1992132080A5006329090 @default.
• W1992132080 hasAuthorship W1992132080A5006544711 @default.
• W1992132080 hasAuthorship W1992132080A5037997257 @default.
• W1992132080 hasAuthorship W1992132080A5051874658 @default.
• W1992132080 hasAuthorship W1992132080A5053105437 @default.
• W1992132080 hasAuthorship W1992132080A5063639436 @default.
• W1992132080 hasAuthorship W1992132080A5071080155 @default.
• W1992132080 hasAuthorship W1992132080A5082724673 @default.
• W1992132080 hasConcept C150903083 @default.
• W1992132080 hasConcept C161176658 @default.
• W1992132080 hasConcept C185592680 @default.
• W1992132080 hasConcept C202751555 @default.
• W1992132080 hasConcept C203014093 @default.
• W1992132080 hasConcept C207001950 @default.
• W1992132080 hasConcept C2777477808 @default.
• W1992132080 hasConcept C2778690821 @default.
• W1992132080 hasConcept C2778863655 @default.
• W1992132080 hasConcept C55493867 @default.
• W1992132080 hasConcept C6557445 @default.
• W1992132080 hasConcept C86803240 @default.
• W1992132080 hasConcept C8891405 @default.
• W1992132080 hasConcept C98274493 @default.
• W1992132080 hasConceptScore W1992132080C150903083 @default.
• W1992132080 hasConceptScore W1992132080C161176658 @default.
• W1992132080 hasConceptScore W1992132080C185592680 @default.
• W1992132080 hasConceptScore W1992132080C202751555 @default.
• W1992132080 hasConceptScore W1992132080C203014093 @default.
• W1992132080 hasConceptScore W1992132080C207001950 @default.
• W1992132080 hasConceptScore W1992132080C2777477808 @default.
• W1992132080 hasConceptScore W1992132080C2778690821 @default.
• W1992132080 hasConceptScore W1992132080C2778863655 @default.
• W1992132080 hasConceptScore W1992132080C55493867 @default.
• W1992132080 hasConceptScore W1992132080C6557445 @default.
• W1992132080 hasConceptScore W1992132080C86803240 @default.
• W1992132080 hasConceptScore W1992132080C8891405 @default.
• W1992132080 hasConceptScore W1992132080C98274493 @default.
• W1992132080 hasIssue "2" @default.
• W1992132080 hasLocation W19921320801 @default.
• W1992132080 hasLocation W19921320802 @default.
• W1992132080 hasOpenAccess W1992132080 @default.
• W1992132080 hasPrimaryLocation W19921320801 @default.
• W1992132080 hasRelatedWork W1963940212 @default.
• W1992132080 hasRelatedWork W1983855168 @default.

• next