FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992133603> ?p ?o ?g. }

• W1992133603 endingPage "18593" @default.
• W1992133603 startingPage "18586" @default.
• W1992133603 abstract "We previously characterized nucleoredoxin (NRX) as a negative regulator of the Wnt signaling pathway through Dishevelled (Dvl). We perform a comprehensive search for other NRX-interacting proteins and identify Flightless-I (Fli-I) as a novel NRX-binding partner. Fli-I binds to NRX and other related proteins, such as Rod-derived cone viability factor (RdCVF), whereas Dvl binds only to NRX. Endogenous NRX and Fli-I in vivo interactions are confirmed. Both NRX and RdCVF link Fli-I with myeloid differentiation primary response gene (88) (MyD88), an important adaptor protein for innate immune response. NRX and RdCVF also potentiate the negative effect of Fli-I upon lipopolysaccharide-induced activation of NF-kappaB through the Toll-like receptor 4/MyD88 pathway. Embryonic fibroblasts derived from NRX gene-targeted mice show aberrant NF-kappaB activation upon lipopolysaccharide stimulation. These results suggest that the NRX subfamily of proteins forms a link between MyD88 and Fli-I to mediate negative regulation of the Toll-like receptor 4/MyD88 pathway." @default.
• W1992133603 created "2016-06-24" @default.
• W1992133603 creator A5000682920 @default.
• W1992133603 creator A5003411661 @default.
• W1992133603 creator A5007753663 @default.
• W1992133603 creator A5032618095 @default.
• W1992133603 creator A5049979270 @default.
• W1992133603 creator A5058440057 @default.
• W1992133603 creator A5070156774 @default.
• W1992133603 creator A5075717037 @default.
• W1992133603 creator A5078464293 @default.
• W1992133603 date "2010-06-01" @default.
• W1992133603 modified "2023-10-18" @default.
• W1992133603 title "Nucleoredoxin Negatively Regulates Toll-like Receptor 4 Signaling via Recruitment of Flightless-I to Myeloid Differentiation Primary Response Gene (88)" @default.
• W1992133603 cites W1925705209 @default.
• W1992133603 cites W1926287324 @default.
• W1992133603 cites W1975945284 @default.
• W1992133603 cites W1978115221 @default.
• W1992133603 cites W1979892210 @default.
• W1992133603 cites W1982021133 @default.
• W1992133603 cites W2002345676 @default.
• W1992133603 cites W2016231119 @default.
• W1992133603 cites W2019532871 @default.
• W1992133603 cites W2019964232 @default.
• W1992133603 cites W2027113655 @default.
• W1992133603 cites W2027414519 @default.
• W1992133603 cites W2050083026 @default.
• W1992133603 cites W2053520824 @default.
• W1992133603 cites W2062080431 @default.
• W1992133603 cites W2073355679 @default.
• W1992133603 cites W2077576116 @default.
• W1992133603 cites W2080472557 @default.
• W1992133603 cites W2083954183 @default.
• W1992133603 cites W2106110723 @default.
• W1992133603 cites W2107648723 @default.
• W1992133603 cites W2108775346 @default.
• W1992133603 cites W2115185894 @default.
• W1992133603 cites W2122306770 @default.
• W1992133603 cites W2130271360 @default.
• W1992133603 cites W2150733880 @default.
• W1992133603 cites W4211252435 @default.
• W1992133603 cites W4246077736 @default.
• W1992133603 cites W4248219898 @default.
• W1992133603 cites W96938930 @default.
• W1992133603 doi "https://doi.org/10.1074/jbc.m110.106468" @default.
• W1992133603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2881784" @default.
• W1992133603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20400501" @default.
• W1992133603 hasPublicationYear "2010" @default.
• W1992133603 type Work @default.
• W1992133603 sameAs 1992133603 @default.
• W1992133603 citedByCount "32" @default.
• W1992133603 countsByYear W19921336032012 @default.
• W1992133603 countsByYear W19921336032013 @default.
• W1992133603 countsByYear W19921336032014 @default.
• W1992133603 countsByYear W19921336032015 @default.
• W1992133603 countsByYear W19921336032016 @default.
• W1992133603 countsByYear W19921336032017 @default.
• W1992133603 countsByYear W19921336032018 @default.
• W1992133603 countsByYear W19921336032020 @default.
• W1992133603 countsByYear W19921336032021 @default.
• W1992133603 countsByYear W19921336032022 @default.
• W1992133603 crossrefType "journal-article" @default.
• W1992133603 hasAuthorship W1992133603A5000682920 @default.
• W1992133603 hasAuthorship W1992133603A5003411661 @default.
• W1992133603 hasAuthorship W1992133603A5007753663 @default.
• W1992133603 hasAuthorship W1992133603A5032618095 @default.
• W1992133603 hasAuthorship W1992133603A5049979270 @default.
• W1992133603 hasAuthorship W1992133603A5058440057 @default.
• W1992133603 hasAuthorship W1992133603A5070156774 @default.
• W1992133603 hasAuthorship W1992133603A5075717037 @default.
• W1992133603 hasAuthorship W1992133603A5078464293 @default.
• W1992133603 hasBestOaLocation W19921336031 @default.
• W1992133603 hasConcept C107300179 @default.
• W1992133603 hasConcept C136449434 @default.
• W1992133603 hasConcept C137620995 @default.
• W1992133603 hasConcept C170493617 @default.
• W1992133603 hasConcept C183786373 @default.
• W1992133603 hasConcept C2775928862 @default.
• W1992133603 hasConcept C2776709828 @default.
• W1992133603 hasConcept C54355233 @default.
• W1992133603 hasConcept C62478195 @default.
• W1992133603 hasConcept C86803240 @default.
• W1992133603 hasConcept C95444343 @default.
• W1992133603 hasConceptScore W1992133603C107300179 @default.
• W1992133603 hasConceptScore W1992133603C136449434 @default.
• W1992133603 hasConceptScore W1992133603C137620995 @default.
• W1992133603 hasConceptScore W1992133603C170493617 @default.
• W1992133603 hasConceptScore W1992133603C183786373 @default.
• W1992133603 hasConceptScore W1992133603C2775928862 @default.
• W1992133603 hasConceptScore W1992133603C2776709828 @default.
• W1992133603 hasConceptScore W1992133603C54355233 @default.
• W1992133603 hasConceptScore W1992133603C62478195 @default.
• W1992133603 hasConceptScore W1992133603C86803240 @default.
• W1992133603 hasConceptScore W1992133603C95444343 @default.
• W1992133603 hasIssue "24" @default.
• W1992133603 hasLocation W19921336031 @default.
• W1992133603 hasLocation W19921336032 @default.
• W1992133603 hasLocation W19921336033 @default.

• next