Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992138870> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1992138870 endingPage "400" @default.
- W1992138870 startingPage "396" @default.
- W1992138870 abstract "The inflammasome is a key component of the innate immune system providing the initial defense against invading organisms. Failure of inflammasome formation is the main reason for many innate and acquired immune diseases. Cytosolic protein absent in melanoma 2 (AIM2) has been reported to play an essential role in double-stranded DNA (dsDNA) sensing and inflammasome formation in response to viruses or bacteria infection. The N-terminal pyrin domain (PYD) of AIM2 interacts with the ASC PYD domain, and then recruits downstream proteins to assemble the AIM2 inflammasome. The molecular mechanisms of PYD mediated signaling remain elusive as limited structural information on PYD family. Herein, we characterized the solution structure of mouse AIM2 PYD domain by NMR spectroscopy, and compared it with the crystal structures of its two human homologues. The comparison shows mAIM2 PYD adopts a unique α2–α3 helix conformation distinct from its human homologues, but similar to the pyrin domain of human NLRP10/PYNOD, which belongs to another family. In addition, the aggregation of mAIM2 PYD domain, with the increased salt concentration, reveals that both the charge surface and hydrophobic interaction play important roles in the self-association of mAIM2 PYD." @default.
- W1992138870 created "2016-06-24" @default.
- W1992138870 creator A5030762213 @default.
- W1992138870 creator A5089673052 @default.
- W1992138870 date "2015-05-01" @default.
- W1992138870 modified "2023-10-16" @default.
- W1992138870 title "The NMR solution structure of AIM2 PYD domain from Mus musculus reveals a distinct α2–α3 helix conformation from its human homologues" @default.
- W1992138870 cites W1589295940 @default.
- W1992138870 cites W1894575361 @default.
- W1992138870 cites W1975136966 @default.
- W1992138870 cites W1975152145 @default.
- W1992138870 cites W1975459052 @default.
- W1992138870 cites W1983072212 @default.
- W1992138870 cites W1995017064 @default.
- W1992138870 cites W2002195659 @default.
- W1992138870 cites W2042288276 @default.
- W1992138870 cites W2042816890 @default.
- W1992138870 cites W2050449334 @default.
- W1992138870 cites W2053202752 @default.
- W1992138870 cites W2053352311 @default.
- W1992138870 cites W2064512362 @default.
- W1992138870 cites W2070784293 @default.
- W1992138870 cites W2072118838 @default.
- W1992138870 cites W2073561387 @default.
- W1992138870 cites W2077730689 @default.
- W1992138870 cites W2092702270 @default.
- W1992138870 cites W2098613471 @default.
- W1992138870 cites W2103200355 @default.
- W1992138870 cites W2104195963 @default.
- W1992138870 cites W2127425186 @default.
- W1992138870 cites W2157305255 @default.
- W1992138870 cites W2169707043 @default.
- W1992138870 cites W2169821755 @default.
- W1992138870 cites W4211217520 @default.
- W1992138870 doi "https://doi.org/10.1016/j.bbrc.2015.04.046" @default.
- W1992138870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25888795" @default.
- W1992138870 hasPublicationYear "2015" @default.
- W1992138870 type Work @default.
- W1992138870 sameAs 1992138870 @default.
- W1992138870 citedByCount "10" @default.
- W1992138870 countsByYear W19921388702015 @default.
- W1992138870 countsByYear W19921388702016 @default.
- W1992138870 countsByYear W19921388702017 @default.
- W1992138870 countsByYear W19921388702018 @default.
- W1992138870 countsByYear W19921388702019 @default.
- W1992138870 countsByYear W19921388702020 @default.
- W1992138870 countsByYear W19921388702021 @default.
- W1992138870 countsByYear W19921388702022 @default.
- W1992138870 crossrefType "journal-article" @default.
- W1992138870 hasAuthorship W1992138870A5030762213 @default.
- W1992138870 hasAuthorship W1992138870A5089673052 @default.
- W1992138870 hasConcept C136449434 @default.
- W1992138870 hasConcept C139174496 @default.
- W1992138870 hasConcept C170493617 @default.
- W1992138870 hasConcept C185592680 @default.
- W1992138870 hasConcept C187831198 @default.
- W1992138870 hasConcept C191120209 @default.
- W1992138870 hasConcept C2777209026 @default.
- W1992138870 hasConcept C47701112 @default.
- W1992138870 hasConcept C54355233 @default.
- W1992138870 hasConcept C55493867 @default.
- W1992138870 hasConcept C86803240 @default.
- W1992138870 hasConcept C8891405 @default.
- W1992138870 hasConcept C95444343 @default.
- W1992138870 hasConceptScore W1992138870C136449434 @default.
- W1992138870 hasConceptScore W1992138870C139174496 @default.
- W1992138870 hasConceptScore W1992138870C170493617 @default.
- W1992138870 hasConceptScore W1992138870C185592680 @default.
- W1992138870 hasConceptScore W1992138870C187831198 @default.
- W1992138870 hasConceptScore W1992138870C191120209 @default.
- W1992138870 hasConceptScore W1992138870C2777209026 @default.
- W1992138870 hasConceptScore W1992138870C47701112 @default.
- W1992138870 hasConceptScore W1992138870C54355233 @default.
- W1992138870 hasConceptScore W1992138870C55493867 @default.
- W1992138870 hasConceptScore W1992138870C86803240 @default.
- W1992138870 hasConceptScore W1992138870C8891405 @default.
- W1992138870 hasConceptScore W1992138870C95444343 @default.
- W1992138870 hasFunder F4320321001 @default.
- W1992138870 hasIssue "2" @default.
- W1992138870 hasLocation W19921388701 @default.
- W1992138870 hasLocation W19921388702 @default.
- W1992138870 hasOpenAccess W1992138870 @default.
- W1992138870 hasPrimaryLocation W19921388701 @default.
- W1992138870 hasRelatedWork W1538346717 @default.
- W1992138870 hasRelatedWork W2008631375 @default.
- W1992138870 hasRelatedWork W2771736620 @default.
- W1992138870 hasRelatedWork W3108760246 @default.
- W1992138870 hasRelatedWork W3115006558 @default.
- W1992138870 hasRelatedWork W3153624090 @default.
- W1992138870 hasRelatedWork W3170880456 @default.
- W1992138870 hasRelatedWork W4248878742 @default.
- W1992138870 hasRelatedWork W4297229765 @default.
- W1992138870 hasRelatedWork W4310367351 @default.
- W1992138870 hasVolume "461" @default.
- W1992138870 isParatext "false" @default.
- W1992138870 isRetracted "false" @default.
- W1992138870 magId "1992138870" @default.
- W1992138870 workType "article" @default.