Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992142485> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1992142485 endingPage "81" @default.
- W1992142485 startingPage "73" @default.
- W1992142485 abstract "A short-term assay utilizing a human/mouse monochromosomal hybrid cell line R3-5, to detect chemically induced aneuploidy in mammalian cells is described. A single human chromosome transferred into mouse cells was used as a cytogenetic marker to quantitate abnormal chromosome segregation following chemical treatment. The human chromosome present in the mouse cells can be readily identified by differential staining procedures. The frequency of cells containing 0 or 2 human chromosomes in the progeny of chemically treated monochromosomal hybrid cells provided a direct measure of aneuploidy. We tested the sensitivity of the proposed system with 3 model chemicals (colcemid, cyclophosphamide and benomyl) known to induce numerical or structural changes in chromosomes. The frequency of an abnormal segregation of the human chromosome was found to be dose dependent and consistently higher than controls. This system has the capability to detect gain as well as loss of a chromosome resulting from nondisjunction or other mechanisms leading to aneuploidy." @default.
- W1992142485 created "2016-06-24" @default.
- W1992142485 creator A5037081528 @default.
- W1992142485 creator A5082174556 @default.
- W1992142485 date "1985-03-01" @default.
- W1992142485 modified "2023-09-28" @default.
- W1992142485 title "Use of human × mouse hybrid cell line to detect aneuploidy induced by environmental chemicals" @default.
- W1992142485 cites W1501000023 @default.
- W1992142485 cites W1592904750 @default.
- W1992142485 cites W1979838808 @default.
- W1992142485 cites W1980826960 @default.
- W1992142485 cites W1986600419 @default.
- W1992142485 cites W1992237040 @default.
- W1992142485 cites W1995542027 @default.
- W1992142485 cites W2012252163 @default.
- W1992142485 cites W2016520189 @default.
- W1992142485 cites W2021415766 @default.
- W1992142485 cites W2027404754 @default.
- W1992142485 cites W2028813398 @default.
- W1992142485 cites W2028875652 @default.
- W1992142485 cites W2029714773 @default.
- W1992142485 cites W2042939205 @default.
- W1992142485 cites W2067968842 @default.
- W1992142485 cites W2072737968 @default.
- W1992142485 cites W2072751819 @default.
- W1992142485 cites W2073272775 @default.
- W1992142485 cites W2075690432 @default.
- W1992142485 cites W2075928693 @default.
- W1992142485 cites W2089565150 @default.
- W1992142485 cites W2108592597 @default.
- W1992142485 cites W2132959112 @default.
- W1992142485 cites W2137497507 @default.
- W1992142485 cites W2157428973 @default.
- W1992142485 cites W2168839211 @default.
- W1992142485 cites W2518094465 @default.
- W1992142485 doi "https://doi.org/10.1016/0027-5107(85)90011-9" @default.
- W1992142485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3974624" @default.
- W1992142485 hasPublicationYear "1985" @default.
- W1992142485 type Work @default.
- W1992142485 sameAs 1992142485 @default.
- W1992142485 citedByCount "40" @default.
- W1992142485 countsByYear W19921424852017 @default.
- W1992142485 countsByYear W19921424852019 @default.
- W1992142485 crossrefType "journal-article" @default.
- W1992142485 hasAuthorship W1992142485A5037081528 @default.
- W1992142485 hasAuthorship W1992142485A5082174556 @default.
- W1992142485 hasConcept C104317684 @default.
- W1992142485 hasConcept C153911025 @default.
- W1992142485 hasConcept C173372395 @default.
- W1992142485 hasConcept C2776095844 @default.
- W1992142485 hasConcept C2779066155 @default.
- W1992142485 hasConcept C2779672484 @default.
- W1992142485 hasConcept C30481170 @default.
- W1992142485 hasConcept C54355233 @default.
- W1992142485 hasConcept C70278784 @default.
- W1992142485 hasConcept C74864618 @default.
- W1992142485 hasConcept C81885089 @default.
- W1992142485 hasConcept C86803240 @default.
- W1992142485 hasConceptScore W1992142485C104317684 @default.
- W1992142485 hasConceptScore W1992142485C153911025 @default.
- W1992142485 hasConceptScore W1992142485C173372395 @default.
- W1992142485 hasConceptScore W1992142485C2776095844 @default.
- W1992142485 hasConceptScore W1992142485C2779066155 @default.
- W1992142485 hasConceptScore W1992142485C2779672484 @default.
- W1992142485 hasConceptScore W1992142485C30481170 @default.
- W1992142485 hasConceptScore W1992142485C54355233 @default.
- W1992142485 hasConceptScore W1992142485C70278784 @default.
- W1992142485 hasConceptScore W1992142485C74864618 @default.
- W1992142485 hasConceptScore W1992142485C81885089 @default.
- W1992142485 hasConceptScore W1992142485C86803240 @default.
- W1992142485 hasIssue "1" @default.
- W1992142485 hasLocation W19921424851 @default.
- W1992142485 hasLocation W19921424852 @default.
- W1992142485 hasOpenAccess W1992142485 @default.
- W1992142485 hasPrimaryLocation W19921424851 @default.
- W1992142485 hasRelatedWork W1992142485 @default.
- W1992142485 hasRelatedWork W2007907792 @default.
- W1992142485 hasRelatedWork W2025213472 @default.
- W1992142485 hasRelatedWork W2086885988 @default.
- W1992142485 hasRelatedWork W2088962131 @default.
- W1992142485 hasRelatedWork W2115438823 @default.
- W1992142485 hasRelatedWork W2397252938 @default.
- W1992142485 hasRelatedWork W2400263661 @default.
- W1992142485 hasRelatedWork W2428699530 @default.
- W1992142485 hasRelatedWork W4289962917 @default.
- W1992142485 hasVolume "149" @default.
- W1992142485 isParatext "false" @default.
- W1992142485 isRetracted "false" @default.
- W1992142485 magId "1992142485" @default.
- W1992142485 workType "article" @default.