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- W1992157082 abstract "4-Amino-1,2-dihydro-5-(2-hydroxyphenyl)-3H-pyrazol-3-ones 2a–c and 5-amino-6-(2-hydroxyphenyl)pyrimidin-4(3H)-ones 3a–f were synthesized from 4-methoxy- and 4-hydroxy-3-nitrocoumarins, and tested for analgesic activity upon oral administration to mice. Most of the compounds prepared exhibited analgesic activity which was superior to that of aminopyrine. In particular, 2a–c and 3a, d showed prominent activity which was 3–4.5 times as potent as that of aminopyrine. Les amino-4 dihydro-1,2 (hydroxy-2 phényl)-5 pyrazol(3H)-ones-3 2a–c et les amino-5 (hydroxy-2 phényl)-6 pyrimidin(3H)-ones-4 3a–f ont été synthétisés à partir des méthoxy-4 et hydroxy-4 nitro-3 coumarines, et leur activité analgésique a étéétudiée par voie orale chez la souris. La plupart des composés ont manifesté une activité analgésique supérieure à celle de l'aminopyrine. En particulier, 2a–c et 3a, d ont montré une activité 3–4,5 fois plus forte que celle de l'aminopyrine." @default.
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- W1992157082 date "1987-05-01" @default.
- W1992157082 modified "2023-09-27" @default.
- W1992157082 title "Synthesis and analgesic activity of 4-amino-1,2-dihydro-5-(2-hydroxyphenyl)-3H-pyrazol-3-ones and 5-amino-6-(2-hydroxyphenyl)pyrimidin-4(3H)-ones" @default.
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- W1992157082 doi "https://doi.org/10.1016/0223-5234(87)90055-9" @default.
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