FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992163543> ?p ?o ?g. }

• W1992163543 endingPage "701" @default.
• W1992163543 startingPage "697" @default.
• W1992163543 abstract "Naringin (Nar) is a flavonoid that has shown antigenotoxic effect against the chromosome damage induced by various compounds. The aims of the present investigation on Nar were threefold: a) to determine its DNA breaking potential in mouse hepatocytes and cardiocytes, b) to evaluate its capacity to inhibit the DNA damage induced by daunorubicin (Dau) in the same tissues, and c) to determine its capacity to trap free radicals in vitro using the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) method. For the two first purposes we applied the comet assay to three groups of animals administered with Nar by the oral route (50, 250, 500 mg/kg), and made the observations before the chemical administration and at 3, 12, and 21 h postadministration. Other three groups of mice were given equal doses of Nar, and 1 h later they were intraperitoneally injected with 1 mg/kg of Dau. The results showed that Nar did not induce DNA breakage in both types of studied cells, in contrast with the significant damage induced by Dau in hepatocytes and cardiocytes. Moreover, the administration of Nar protected the DNA damage produced by Dau, showing a maximum reduction of 71.3% and 51.1% in hepatocytes and cardiocytes, respectively. With respect to the antioxidant potential, 20 mM of Nar produced a free radical scavenging activity as high as 95%. Our study established a high DNA breaking potential of Dau, and a protective effect by Nar, probably related with its capacity to trap free radicals." @default.
• W1992163543 created "2016-06-24" @default.
• W1992163543 creator A5060875661 @default.
• W1992163543 creator A5067479413 @default.
• W1992163543 creator A5068803276 @default.
• W1992163543 creator A5081064553 @default.
• W1992163543 date "2010-01-01" @default.
• W1992163543 modified "2023-10-17" @default.
• W1992163543 title "Effect of Naringin on the DNA Damage Induced by Daunorubicin in Mouse Hepatocytes and Cardiocytes" @default.
• W1992163543 cites W1523397215 @default.
• W1992163543 cites W1853037896 @default.
• W1992163543 cites W1985760667 @default.
• W1992163543 cites W1996399654 @default.
• W1992163543 cites W2003366674 @default.
• W1992163543 cites W2013588043 @default.
• W1992163543 cites W2017164046 @default.
• W1992163543 cites W2019354174 @default.
• W1992163543 cites W2029417917 @default.
• W1992163543 cites W2030353912 @default.
• W1992163543 cites W2032474965 @default.
• W1992163543 cites W2033410404 @default.
• W1992163543 cites W2039783607 @default.
• W1992163543 cites W2040850983 @default.
• W1992163543 cites W2046991250 @default.
• W1992163543 cites W2048272954 @default.
• W1992163543 cites W2052979265 @default.
• W1992163543 cites W2059467385 @default.
• W1992163543 cites W2062930966 @default.
• W1992163543 cites W2069077740 @default.
• W1992163543 cites W2079752760 @default.
• W1992163543 cites W2081872634 @default.
• W1992163543 cites W2082260923 @default.
• W1992163543 cites W2085494918 @default.
• W1992163543 cites W2089728326 @default.
• W1992163543 cites W2106926141 @default.
• W1992163543 cites W2113108113 @default.
• W1992163543 cites W2121829036 @default.
• W1992163543 cites W2124928988 @default.
• W1992163543 cites W2126902508 @default.
• W1992163543 cites W2130124282 @default.
• W1992163543 cites W2143593450 @default.
• W1992163543 cites W2154889565 @default.
• W1992163543 cites W2160773582 @default.
• W1992163543 cites W2162826641 @default.
• W1992163543 cites W2165539251 @default.
• W1992163543 cites W2170246294 @default.
• W1992163543 cites W2171836350 @default.
• W1992163543 cites W2187765434 @default.
• W1992163543 cites W2399668446 @default.
• W1992163543 doi "https://doi.org/10.1248/bpb.33.697" @default.
• W1992163543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20410608" @default.
• W1992163543 hasPublicationYear "2010" @default.
• W1992163543 type Work @default.
• W1992163543 sameAs 1992163543 @default.
• W1992163543 citedByCount "22" @default.
• W1992163543 countsByYear W19921635432012 @default.
• W1992163543 countsByYear W19921635432013 @default.
• W1992163543 countsByYear W19921635432014 @default.
• W1992163543 countsByYear W19921635432015 @default.
• W1992163543 countsByYear W19921635432016 @default.
• W1992163543 countsByYear W19921635432017 @default.
• W1992163543 countsByYear W19921635432018 @default.
• W1992163543 countsByYear W19921635432020 @default.
• W1992163543 countsByYear W19921635432021 @default.
• W1992163543 countsByYear W19921635432023 @default.
• W1992163543 crossrefType "journal-article" @default.
• W1992163543 hasAuthorship W1992163543A5060875661 @default.
• W1992163543 hasAuthorship W1992163543A5067479413 @default.
• W1992163543 hasAuthorship W1992163543A5068803276 @default.
• W1992163543 hasAuthorship W1992163543A5081064553 @default.
• W1992163543 hasBestOaLocation W19921635431 @default.
• W1992163543 hasConcept C139066938 @default.
• W1992163543 hasConcept C143425029 @default.
• W1992163543 hasConcept C153911025 @default.
• W1992163543 hasConcept C185592680 @default.
• W1992163543 hasConcept C202751555 @default.
• W1992163543 hasConcept C203014093 @default.
• W1992163543 hasConcept C2777335409 @default.
• W1992163543 hasConcept C2778004101 @default.
• W1992163543 hasConcept C2778461978 @default.
• W1992163543 hasConcept C2779054382 @default.
• W1992163543 hasConcept C2780358455 @default.
• W1992163543 hasConcept C2781021840 @default.
• W1992163543 hasConcept C2781401929 @default.
• W1992163543 hasConcept C43617362 @default.
• W1992163543 hasConcept C552990157 @default.
• W1992163543 hasConcept C55493867 @default.
• W1992163543 hasConcept C86803240 @default.
• W1992163543 hasConcept C98274493 @default.
• W1992163543 hasConceptScore W1992163543C139066938 @default.
• W1992163543 hasConceptScore W1992163543C143425029 @default.
• W1992163543 hasConceptScore W1992163543C153911025 @default.
• W1992163543 hasConceptScore W1992163543C185592680 @default.
• W1992163543 hasConceptScore W1992163543C202751555 @default.
• W1992163543 hasConceptScore W1992163543C203014093 @default.
• W1992163543 hasConceptScore W1992163543C2777335409 @default.
• W1992163543 hasConceptScore W1992163543C2778004101 @default.
• W1992163543 hasConceptScore W1992163543C2778461978 @default.

• next