FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992173694> ?p ?o ?g. }

• W1992173694 endingPage "123" @default.
• W1992173694 startingPage "107" @default.
• W1992173694 abstract "It was previously reported that deletions introduced into the 3'-untranslated region (3'-UTR) of dengue type 4 (DEN 4) virus (Men, R., Bray, M., Clark, D., Chanock, R.M., Lai, C.J., 1996. DEN 4 virus mutants containing deletions in the 3'-noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in Rhesus monkeys. J. Virol. 70, 3930-3937), tick-borne encephalitis (TBE) virus (Mandl, C.W., Holzmann, H., Meixner, T., Rauscher, S., Stadler, P.F., Allison, S.L. , Heinz, F.X., 1998. Spontaneous and engineered deletions in the 3'-noncoding region of TBE virus: construction of highly attenuated mutants of a flavivirus. J. Virol. 72, 2132-2140) and subgenomic replicons of Kunjin virus (Khromykh, A.A., Westaway, E.G., 1997. Subgenomic replicons of the flavivirus Kunjin: construction and applications. J. Virol. 71, 1497-1505) altered the infectivity of the mutants and reduced the efficiency of RNA replication. Here, these deletions were superimposed onto the models of secondary structure we constructed previously and the folding of the modified 3'-UTR sequences was simulated. The analysis showed that most of the deletions disrupted or reshaped conserved elements of secondary structure and that the biological effects of these deletions are likely to represent structural rearrangements in the 3'-UTR, rather than the loss of sequence motifs. The analysis also suggested that the overall structural integrity of the flaviviral 3'-UTR is essential for optimal performance of its promotor function, although two distinct parts can be defined: the most 3'-terminal structures and sequences which may be critical for the initiation of minus-strand RNA synthesis, and more proximal structures and sequences that possibly function as enhancers of viral RNA replication. The functional significance of certain structural elements and their possible effect on the efficiency of viral replication in different cells are also discussed." @default.
• W1992173694 created "2016-06-24" @default.
• W1992173694 creator A5020557120 @default.
• W1992173694 creator A5064244609 @default.
• W1992173694 creator A5079236083 @default.
• W1992173694 creator A5085736091 @default.
• W1992173694 date "1999-11-01" @default.
• W1992173694 modified "2023-10-17" @default.
• W1992173694 title "Biological consequences of deletions within the 3′-untranslated region of flaviviruses may be due to rearrangements of RNA secondary structure" @default.
• W1992173694 cites W1488121527 @default.
• W1992173694 cites W1816614902 @default.
• W1992173694 cites W1830896867 @default.
• W1992173694 cites W1894021355 @default.
• W1992173694 cites W1904496303 @default.
• W1992173694 cites W1948163770 @default.
• W1992173694 cites W1973146472 @default.
• W1992173694 cites W1982090618 @default.
• W1992173694 cites W1983944220 @default.
• W1992173694 cites W1984675364 @default.
• W1992173694 cites W1987977026 @default.
• W1992173694 cites W2005510346 @default.
• W1992173694 cites W2010831852 @default.
• W1992173694 cites W2029365875 @default.
• W1992173694 cites W2034751478 @default.
• W1992173694 cites W2039963086 @default.
• W1992173694 cites W2040015982 @default.
• W1992173694 cites W2048575064 @default.
• W1992173694 cites W2055998285 @default.
• W1992173694 cites W2060878108 @default.
• W1992173694 cites W2068980806 @default.
• W1992173694 cites W2086221905 @default.
• W1992173694 cites W2106494184 @default.
• W1992173694 cites W2129296891 @default.
• W1992173694 cites W2159379501 @default.
• W1992173694 cites W2161387440 @default.
• W1992173694 cites W2186313924 @default.
• W1992173694 doi "https://doi.org/10.1016/s0168-1702(99)00079-9" @default.
• W1992173694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10518708" @default.
• W1992173694 hasPublicationYear "1999" @default.
• W1992173694 type Work @default.
• W1992173694 sameAs 1992173694 @default.
• W1992173694 citedByCount "85" @default.
• W1992173694 countsByYear W19921736942012 @default.
• W1992173694 countsByYear W19921736942013 @default.
• W1992173694 countsByYear W19921736942014 @default.
• W1992173694 countsByYear W19921736942015 @default.
• W1992173694 countsByYear W19921736942016 @default.
• W1992173694 countsByYear W19921736942017 @default.
• W1992173694 countsByYear W19921736942018 @default.
• W1992173694 countsByYear W19921736942019 @default.
• W1992173694 countsByYear W19921736942020 @default.
• W1992173694 countsByYear W19921736942021 @default.
• W1992173694 countsByYear W19921736942022 @default.
• W1992173694 countsByYear W19921736942023 @default.
• W1992173694 crossrefType "journal-article" @default.
• W1992173694 hasAuthorship W1992173694A5020557120 @default.
• W1992173694 hasAuthorship W1992173694A5064244609 @default.
• W1992173694 hasAuthorship W1992173694A5079236083 @default.
• W1992173694 hasAuthorship W1992173694A5085736091 @default.
• W1992173694 hasConcept C104317684 @default.
• W1992173694 hasConcept C141231307 @default.
• W1992173694 hasConcept C159047783 @default.
• W1992173694 hasConcept C18103114 @default.
• W1992173694 hasConcept C189819185 @default.
• W1992173694 hasConcept C2522874641 @default.
• W1992173694 hasConcept C2780568436 @default.
• W1992173694 hasConcept C54355233 @default.
• W1992173694 hasConcept C67705224 @default.
• W1992173694 hasConcept C86803240 @default.
• W1992173694 hasConcept C89604277 @default.
• W1992173694 hasConceptScore W1992173694C104317684 @default.
• W1992173694 hasConceptScore W1992173694C141231307 @default.
• W1992173694 hasConceptScore W1992173694C159047783 @default.
• W1992173694 hasConceptScore W1992173694C18103114 @default.
• W1992173694 hasConceptScore W1992173694C189819185 @default.
• W1992173694 hasConceptScore W1992173694C2522874641 @default.
• W1992173694 hasConceptScore W1992173694C2780568436 @default.
• W1992173694 hasConceptScore W1992173694C54355233 @default.
• W1992173694 hasConceptScore W1992173694C67705224 @default.
• W1992173694 hasConceptScore W1992173694C86803240 @default.
• W1992173694 hasConceptScore W1992173694C89604277 @default.
• W1992173694 hasIssue "2" @default.
• W1992173694 hasLocation W19921736941 @default.
• W1992173694 hasLocation W19921736942 @default.
• W1992173694 hasOpenAccess W1992173694 @default.
• W1992173694 hasPrimaryLocation W19921736941 @default.
• W1992173694 hasRelatedWork W1974733477 @default.
• W1992173694 hasRelatedWork W1988989075 @default.
• W1992173694 hasRelatedWork W2010945216 @default.
• W1992173694 hasRelatedWork W2038451181 @default.
• W1992173694 hasRelatedWork W2062405322 @default.
• W1992173694 hasRelatedWork W2105770276 @default.
• W1992173694 hasRelatedWork W2162352017 @default.
• W1992173694 hasRelatedWork W2380538049 @default.
• W1992173694 hasRelatedWork W2415719708 @default.
• W1992173694 hasRelatedWork W3144489528 @default.
• W1992173694 hasVolume "64" @default.
• W1992173694 isParatext "false" @default.

• next