Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992173801> ?p ?o ?g. }
- W1992173801 endingPage "755" @default.
- W1992173801 startingPage "745" @default.
- W1992173801 abstract "NSCLC is the leading cause of cancer-related death in the US. Patients with NSCLC are mostly treated with platinum-based chemotherapy, often in combination with radiation therapy. However, the development of chemo-resistance is a major hurdle limiting treatment success. In this review, we summarize the current understanding of the genetic factors modulating chemoresistance to platinum chemotherapeutics and their association with clinical outcomes for NSCLC patients. We focus on candidate pathways responsible for drug influx and efflux, metabolism and detoxification, DNA damage repair, and other downstream cellular processes that modulate the effect of platinum-based therapy. We also discuss the application of pathway-based polygenic and genome-wide approaches in identifying genetic factors involved in NSCLC clinical outcomes. Overall, current studies have shown that the effects of each individual polymorphism on clinical outcomes are modest suggesting that a more comprehensive approach that incorporates polygenetic, phenotypic, epidemiologic and clinical variables will be necessary to predict prognosis for NSCLC patients receiving platinum-based chemotherapeutics." @default.
- W1992173801 created "2016-06-24" @default.
- W1992173801 creator A5015664950 @default.
- W1992173801 creator A5050250764 @default.
- W1992173801 creator A5066957198 @default.
- W1992173801 date "2009-05-15" @default.
- W1992173801 modified "2023-10-17" @default.
- W1992173801 title "Pharmacogenomics of platinum-based chemotherapy in NSCLC" @default.
- W1992173801 cites W1604547439 @default.
- W1992173801 cites W1922104747 @default.
- W1992173801 cites W1964927900 @default.
- W1992173801 cites W1966704943 @default.
- W1992173801 cites W1972020976 @default.
- W1992173801 cites W1976843725 @default.
- W1992173801 cites W1985385147 @default.
- W1992173801 cites W1989376781 @default.
- W1992173801 cites W2003291462 @default.
- W1992173801 cites W2004718750 @default.
- W1992173801 cites W2005599761 @default.
- W1992173801 cites W2012428899 @default.
- W1992173801 cites W2013550458 @default.
- W1992173801 cites W2014260980 @default.
- W1992173801 cites W2014966556 @default.
- W1992173801 cites W2017541181 @default.
- W1992173801 cites W2020830322 @default.
- W1992173801 cites W2021825157 @default.
- W1992173801 cites W2028622397 @default.
- W1992173801 cites W2029278190 @default.
- W1992173801 cites W2031967567 @default.
- W1992173801 cites W2043103956 @default.
- W1992173801 cites W2043125282 @default.
- W1992173801 cites W2045293701 @default.
- W1992173801 cites W2045687954 @default.
- W1992173801 cites W2069715487 @default.
- W1992173801 cites W2075230059 @default.
- W1992173801 cites W2075747141 @default.
- W1992173801 cites W2079216966 @default.
- W1992173801 cites W2079620909 @default.
- W1992173801 cites W2081685795 @default.
- W1992173801 cites W2083634237 @default.
- W1992173801 cites W2084001490 @default.
- W1992173801 cites W2084492467 @default.
- W1992173801 cites W2087312216 @default.
- W1992173801 cites W2087542439 @default.
- W1992173801 cites W2090323775 @default.
- W1992173801 cites W2097554668 @default.
- W1992173801 cites W2097692009 @default.
- W1992173801 cites W2099046672 @default.
- W1992173801 cites W2100506495 @default.
- W1992173801 cites W2101172600 @default.
- W1992173801 cites W2101943966 @default.
- W1992173801 cites W2104265571 @default.
- W1992173801 cites W2106059525 @default.
- W1992173801 cites W2107423050 @default.
- W1992173801 cites W2113304916 @default.
- W1992173801 cites W2113363667 @default.
- W1992173801 cites W2114327673 @default.
- W1992173801 cites W2114620947 @default.
- W1992173801 cites W2116521204 @default.
- W1992173801 cites W2117539139 @default.
- W1992173801 cites W2118082971 @default.
- W1992173801 cites W2118951956 @default.
- W1992173801 cites W2120240963 @default.
- W1992173801 cites W2120294133 @default.
- W1992173801 cites W2121277505 @default.
- W1992173801 cites W2123314460 @default.
- W1992173801 cites W2124538547 @default.
- W1992173801 cites W2124714901 @default.
- W1992173801 cites W2126645183 @default.
- W1992173801 cites W2132807006 @default.
- W1992173801 cites W2135836212 @default.
- W1992173801 cites W2139819296 @default.
- W1992173801 cites W2139840013 @default.
- W1992173801 cites W2140877370 @default.
- W1992173801 cites W2142694173 @default.
- W1992173801 cites W2143373549 @default.
- W1992173801 cites W2144733577 @default.
- W1992173801 cites W2145995826 @default.
- W1992173801 cites W2147640394 @default.
- W1992173801 cites W2153507021 @default.
- W1992173801 cites W2153906296 @default.
- W1992173801 cites W2155838479 @default.
- W1992173801 cites W2156613325 @default.
- W1992173801 cites W2158341767 @default.
- W1992173801 cites W2164277862 @default.
- W1992173801 cites W2168655513 @default.
- W1992173801 cites W2171381573 @default.
- W1992173801 cites W2626223149 @default.
- W1992173801 cites W4231681314 @default.
- W1992173801 doi "https://doi.org/10.1517/17425250902973711" @default.
- W1992173801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3417337" @default.
- W1992173801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19442035" @default.
- W1992173801 hasPublicationYear "2009" @default.
- W1992173801 type Work @default.
- W1992173801 sameAs 1992173801 @default.
- W1992173801 citedByCount "61" @default.
- W1992173801 countsByYear W19921738012012 @default.
- W1992173801 countsByYear W19921738012013 @default.