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- W1992178895 abstract "A dysregulated metal homeostasis is associated with both Alzheimer's (AD) and Parkinson's (PD) diseases; AD patients have decreased cortex and elevated serum copper levels along with extracellular amyloid-beta plaques containing copper, iron, and zinc. For AD, a putative hepcidin-mediated lowering of cortex copper mechanism is suggested. An age-related mild chronic inflammation and/or elevated intracellular iron can trigger hepcidin production followed by its binding to ferroportin which is the only neuronal iron exporter, thereby subjecting it to lysosomal degradation. Subsequently raised neuronal iron levels can induce translation of the ferroportin assisting and copper binding amyloid precursor protein (APP); constitutive APP transmembrane passage lowers the copper pool which is important for many enzymes. Using in silico gene expression analyses, we here show significantly decreased expression of copper-dependent enzymes in AD brain and metallothioneins were upregulated in both diseases. Although few AD exposure risk factors are known, AD-related tauopathies can result from cyanobacterial microcystin and β-methylamino-L-alanine (BMAA) intake. Several environmental exposures may represent risk factors for PD; for this disease neurodegeneration is likely to involve mitochondrial dysfunction, microglial activation, and neuroinflammation. Administration of metal chelators and anti-inflammatory agents could affect disease outcomes." @default.
- W1992178895 created "2016-06-24" @default.
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- W1992178895 date "2013-01-01" @default.
- W1992178895 modified "2023-10-16" @default.
- W1992178895 title "Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases: Possible Impact of Environmental Exposures" @default.
- W1992178895 cites W14197507 @default.
- W1992178895 cites W1484568938 @default.
- W1992178895 cites W1516095885 @default.
- W1992178895 cites W1580441010 @default.
- W1992178895 cites W1582485153 @default.
- W1992178895 cites W1637392459 @default.
- W1992178895 cites W1878700164 @default.
- W1992178895 cites W1965277984 @default.
- W1992178895 cites W1965942744 @default.
- W1992178895 cites W1968931382 @default.
- W1992178895 cites W1968938847 @default.
- W1992178895 cites W1969041362 @default.
- W1992178895 cites W1969617718 @default.
- W1992178895 cites W1970032686 @default.
- W1992178895 cites W1970484692 @default.
- W1992178895 cites W1970830035 @default.
- W1992178895 cites W1972742764 @default.
- W1992178895 cites W1972758118 @default.
- W1992178895 cites W1972807774 @default.
- W1992178895 cites W1975121053 @default.
- W1992178895 cites W1975803474 @default.
- W1992178895 cites W1977360731 @default.
- W1992178895 cites W1980042430 @default.
- W1992178895 cites W1980350354 @default.
- W1992178895 cites W1981835221 @default.
- W1992178895 cites W1983263013 @default.
- W1992178895 cites W1984096409 @default.
- W1992178895 cites W1984737307 @default.
- W1992178895 cites W1985001624 @default.
- W1992178895 cites W1987004867 @default.
- W1992178895 cites W1987817022 @default.
- W1992178895 cites W1990115112 @default.
- W1992178895 cites W1990362540 @default.
- W1992178895 cites W1990763168 @default.
- W1992178895 cites W1991805788 @default.
- W1992178895 cites W1994082731 @default.
- W1992178895 cites W1994151063 @default.
- W1992178895 cites W1994946767 @default.
- W1992178895 cites W1996971085 @default.
- W1992178895 cites W1998106951 @default.
- W1992178895 cites W1998639666 @default.
- W1992178895 cites W1999385317 @default.
- W1992178895 cites W1999881215 @default.
- W1992178895 cites W2000349797 @default.
- W1992178895 cites W2000510440 @default.
- W1992178895 cites W2000643475 @default.
- W1992178895 cites W2002181764 @default.
- W1992178895 cites W2002559713 @default.
- W1992178895 cites W2002753168 @default.
- W1992178895 cites W2003215052 @default.
- W1992178895 cites W2004349171 @default.
- W1992178895 cites W2004653921 @default.
- W1992178895 cites W2006909664 @default.
- W1992178895 cites W2009526570 @default.
- W1992178895 cites W2009878128 @default.
- W1992178895 cites W2011657572 @default.
- W1992178895 cites W2014070897 @default.
- W1992178895 cites W2017550829 @default.
- W1992178895 cites W2018225482 @default.
- W1992178895 cites W2018264373 @default.
- W1992178895 cites W2018631912 @default.
- W1992178895 cites W2018986622 @default.
- W1992178895 cites W2019138896 @default.
- W1992178895 cites W2019333118 @default.
- W1992178895 cites W2019628288 @default.
- W1992178895 cites W2019817056 @default.
- W1992178895 cites W2020541351 @default.
- W1992178895 cites W2021177193 @default.
- W1992178895 cites W2028034405 @default.
- W1992178895 cites W2029107495 @default.
- W1992178895 cites W2030021745 @default.
- W1992178895 cites W2030155384 @default.
- W1992178895 cites W2030249003 @default.
- W1992178895 cites W2032146145 @default.
- W1992178895 cites W2032602280 @default.
- W1992178895 cites W2034284309 @default.
- W1992178895 cites W2036425957 @default.
- W1992178895 cites W2036956824 @default.
- W1992178895 cites W2037394838 @default.
- W1992178895 cites W2039517040 @default.
- W1992178895 cites W2040584350 @default.
- W1992178895 cites W2041317303 @default.
- W1992178895 cites W2041712566 @default.
- W1992178895 cites W2043099341 @default.
- W1992178895 cites W2045262404 @default.
- W1992178895 cites W2047701363 @default.
- W1992178895 cites W2048897966 @default.
- W1992178895 cites W2049387807 @default.