FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992181211> ?p ?o ?g. }

• W1992181211 endingPage "4007" @default.
• W1992181211 startingPage "4001" @default.
• W1992181211 abstract "The mammalian prion protein (PrP c ) is a cellular protein of unknown function, an altered isoform of which (PrP sc ) is a component of the infectious particle (prion) thought to be responsible for spongiform encephalopathies In humans and animals. The evolutionary conservation of the PrP gene has been reported in the genomes of many vertebrates as well as certain invertebrates. In the genome of nematode Caenorhabditis elegans , the sequence capable of hybridizing with the mammalian PrP cDNA probe has been demonstrated, predicting the presence of the PrP gene homologue in C.elegans. In this study, Southern analysis with the hamster PrP cDNA (HaPrP) probe confirmed the previous observation. Moreover, Northern analysis revealed that the sequence is actively transcribed in adult worms. Thus, we screened C.elegans cDNA libraries with the HaPrP probe and isolated a cDNA that hybridizes to the same sequence in C.elegans that hybridized with the HaPrP probe in the Southern and Northern analyses. The deduced amino acid sequence of this cDNA, however, is substantially homologous with heterogeneous nuclear ribonucleoprotein (hnRNP) core proteins rather than mammalian PrP c . The hnRNPs contain the glycine-rich domain in the C-terminal half of the molecule, which also seemed to be in PrP ° at the N-terminal half of the molecule. Both of the glycine-rich domains are composed of tracts with high G + C content, indicating that these tracts may due to the hybridizing signals. These results suggest that this cDNA clone is derived from a novel hnRNP gene homologue in C.elegans but not from a predicted PrP gene homologue." @default.
• W1992181211 created "2016-06-24" @default.
• W1992181211 creator A5046511815 @default.
• W1992181211 creator A5052960327 @default.
• W1992181211 creator A5063543953 @default.
• W1992181211 creator A5073048235 @default.
• W1992181211 creator A5083599828 @default.
• W1992181211 date "1992-01-01" @default.
• W1992181211 modified "2023-09-25" @default.
• W1992181211 title "cDNA cloning of a novel heterogeneous nuclear ribonucleoprotein gene homologue in<i>Caenorhabditis elegans</i>using hamster prion protein cDNA as a hybridization probe" @default.
• W1992181211 cites W127427893 @default.
• W1992181211 cites W1555057470 @default.
• W1992181211 cites W1944127002 @default.
• W1992181211 cites W1965755240 @default.
• W1992181211 cites W1966003712 @default.
• W1992181211 cites W1966848792 @default.
• W1992181211 cites W1984770885 @default.
• W1992181211 cites W1985969245 @default.
• W1992181211 cites W1990497827 @default.
• W1992181211 cites W2001160033 @default.
• W1992181211 cites W2013568111 @default.
• W1992181211 cites W2013679718 @default.
• W1992181211 cites W2016192073 @default.
• W1992181211 cites W2021505439 @default.
• W1992181211 cites W2027593556 @default.
• W1992181211 cites W2028796198 @default.
• W1992181211 cites W2029195137 @default.
• W1992181211 cites W2033367680 @default.
• W1992181211 cites W2035349586 @default.
• W1992181211 cites W2043979078 @default.
• W1992181211 cites W2051968416 @default.
• W1992181211 cites W2074400407 @default.
• W1992181211 cites W2076847487 @default.
• W1992181211 cites W2078871113 @default.
• W1992181211 cites W2110420813 @default.
• W1992181211 cites W2115470684 @default.
• W1992181211 cites W2115708583 @default.
• W1992181211 cites W2138270253 @default.
• W1992181211 cites W2168847939 @default.
• W1992181211 cites W2411707786 @default.
• W1992181211 doi "https://doi.org/10.1093/nar/20.15.4001" @default.
• W1992181211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/334079" @default.
• W1992181211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1354852" @default.
• W1992181211 hasPublicationYear "1992" @default.
• W1992181211 type Work @default.
• W1992181211 sameAs 1992181211 @default.
• W1992181211 citedByCount "9" @default.
• W1992181211 crossrefType "journal-article" @default.
• W1992181211 hasAuthorship W1992181211A5046511815 @default.
• W1992181211 hasAuthorship W1992181211A5052960327 @default.
• W1992181211 hasAuthorship W1992181211A5063543953 @default.
• W1992181211 hasAuthorship W1992181211A5073048235 @default.
• W1992181211 hasAuthorship W1992181211A5083599828 @default.
• W1992181211 hasBestOaLocation W19921812111 @default.
• W1992181211 hasConcept C104317684 @default.
• W1992181211 hasConcept C153911025 @default.
• W1992181211 hasConcept C159194896 @default.
• W1992181211 hasConcept C167625842 @default.
• W1992181211 hasConcept C187882448 @default.
• W1992181211 hasConcept C189482833 @default.
• W1992181211 hasConcept C2776496032 @default.
• W1992181211 hasConcept C2778944004 @default.
• W1992181211 hasConcept C2909472194 @default.
• W1992181211 hasConcept C54355233 @default.
• W1992181211 hasConcept C67705224 @default.
• W1992181211 hasConcept C75934600 @default.
• W1992181211 hasConcept C86803240 @default.
• W1992181211 hasConceptScore W1992181211C104317684 @default.
• W1992181211 hasConceptScore W1992181211C153911025 @default.
• W1992181211 hasConceptScore W1992181211C159194896 @default.
• W1992181211 hasConceptScore W1992181211C167625842 @default.
• W1992181211 hasConceptScore W1992181211C187882448 @default.
• W1992181211 hasConceptScore W1992181211C189482833 @default.
• W1992181211 hasConceptScore W1992181211C2776496032 @default.
• W1992181211 hasConceptScore W1992181211C2778944004 @default.
• W1992181211 hasConceptScore W1992181211C2909472194 @default.
• W1992181211 hasConceptScore W1992181211C54355233 @default.
• W1992181211 hasConceptScore W1992181211C67705224 @default.
• W1992181211 hasConceptScore W1992181211C75934600 @default.
• W1992181211 hasConceptScore W1992181211C86803240 @default.
• W1992181211 hasIssue "15" @default.
• W1992181211 hasLocation W19921812111 @default.
• W1992181211 hasLocation W19921812112 @default.
• W1992181211 hasLocation W19921812113 @default.
• W1992181211 hasOpenAccess W1992181211 @default.
• W1992181211 hasPrimaryLocation W19921812111 @default.
• W1992181211 hasRelatedWork W1809349505 @default.
• W1992181211 hasRelatedWork W1946787458 @default.
• W1992181211 hasRelatedWork W1974283070 @default.
• W1992181211 hasRelatedWork W1988839698 @default.
• W1992181211 hasRelatedWork W1991349199 @default.
• W1992181211 hasRelatedWork W1992181211 @default.
• W1992181211 hasRelatedWork W2015157953 @default.
• W1992181211 hasRelatedWork W2125731289 @default.
• W1992181211 hasRelatedWork W2151285918 @default.
• W1992181211 hasRelatedWork W2157166663 @default.
• W1992181211 hasVolume "20" @default.
• W1992181211 isParatext "false" @default.

• next