FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992182110> ?p ?o ?g. }

• W1992182110 endingPage "21" @default.
• W1992182110 startingPage "14" @default.
• W1992182110 abstract "The effect of human IgG on human haemopolesis has been studied in vitro. Dialysed purified IgG stimulated haemopoletic colony growth by bone marrow mononuclear cells (MNC) but not by monocyte-depleted MNC. Culture media, conditioned by IgG-stimulated peripheral blood MNC, augmented formation of neutrophil-macrophage, eosinophil, and megakaryocyte colonies by monocyte-depleted marrow MNC. Serum-free IgG-conditioned media also contained colony-stimulating activity (CSA). IgG Fc fragments and heat-aggregated IgG promoted the secretion of CSA, but F(ab′)2 fragments, Fab fragments or ultracentrifuged IgG did not. In the cell-selection studies, CSA was produced by highly enriched monocytes following stimulation with Fc fragments. The antiserum against human granulocyte colony-stimulating factor (G-CSF) and/or granulocyte-macrophage CSF (GM-CSF) neutralized the CSA produced by Fc fragment-activated monocytes. Enzyme immunoassays showed G-CSF and GM-CSF in media conditioned by monocytes stimulated with the Fc fragments, heat-aggregated IgG and anti-D-sensitized red blood cells (RBC). Northern hybridization analysis showed mRNA encoding G-CSF and GM-CSF in RNA extracted from MNC and monocytes cultured with the Fc fragments, but not in the RNA from unstimulated cells or monocyte-depleted MNC. These results indicate that IgG Fc fragments, aggregated IgG and antigen-antibody complexes induce monocytes to produce G-CSF and GM-CSF in vitro. The CSFs release induced by IgG may be involved in the in vivo regulatory network in haemopoiesis." @default.
• W1992182110 created "2016-06-24" @default.
• W1992182110 creator A5013169655 @default.
• W1992182110 creator A5019577667 @default.
• W1992182110 creator A5030021970 @default.
• W1992182110 creator A5061148658 @default.
• W1992182110 creator A5069725535 @default.
• W1992182110 creator A5078215577 @default.
• W1992182110 date "1991-09-01" @default.
• W1992182110 modified "2023-09-26" @default.
• W1992182110 title "Induction of granulocyte and granulocyte-macrophage colony-stimulating factors from human monocytes stimulated by Fc fragments of human IgG" @default.
• W1992182110 cites W1459538898 @default.
• W1992182110 cites W1576381578 @default.
• W1992182110 cites W1973312385 @default.
• W1992182110 cites W1977157092 @default.
• W1992182110 cites W1984966253 @default.
• W1992182110 cites W1986450202 @default.
• W1992182110 cites W1989271276 @default.
• W1992182110 cites W1992120471 @default.
• W1992182110 cites W2005589673 @default.
• W1992182110 cites W2011836510 @default.
• W1992182110 cites W2014669590 @default.
• W1992182110 cites W2019162839 @default.
• W1992182110 cites W2019927351 @default.
• W1992182110 cites W2030917541 @default.
• W1992182110 cites W2042371841 @default.
• W1992182110 cites W2042873783 @default.
• W1992182110 cites W2047639340 @default.
• W1992182110 cites W2062042301 @default.
• W1992182110 cites W2068499309 @default.
• W1992182110 cites W2077077811 @default.
• W1992182110 cites W2092368843 @default.
• W1992182110 cites W2100837269 @default.
• W1992182110 cites W2109750471 @default.
• W1992182110 cites W2149724883 @default.
• W1992182110 cites W2210580861 @default.
• W1992182110 cites W234545392 @default.
• W1992182110 cites W2404635794 @default.
• W1992182110 cites W2406384025 @default.
• W1992182110 cites W2408311977 @default.
• W1992182110 cites W2412842174 @default.
• W1992182110 cites W313927096 @default.
• W1992182110 cites W336773932 @default.
• W1992182110 cites W70261316 @default.
• W1992182110 doi "https://doi.org/10.1111/j.1365-2141.1991.tb08000.x" @default.
• W1992182110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1716961" @default.
• W1992182110 hasPublicationYear "1991" @default.
• W1992182110 type Work @default.
• W1992182110 sameAs 1992182110 @default.
• W1992182110 citedByCount "15" @default.
• W1992182110 crossrefType "journal-article" @default.
• W1992182110 hasAuthorship W1992182110A5013169655 @default.
• W1992182110 hasAuthorship W1992182110A5019577667 @default.
• W1992182110 hasAuthorship W1992182110A5030021970 @default.
• W1992182110 hasAuthorship W1992182110A5061148658 @default.
• W1992182110 hasAuthorship W1992182110A5069725535 @default.
• W1992182110 hasAuthorship W1992182110A5078215577 @default.
• W1992182110 hasConcept C109159458 @default.
• W1992182110 hasConcept C137061746 @default.
• W1992182110 hasConcept C153911025 @default.
• W1992182110 hasConcept C159654299 @default.
• W1992182110 hasConcept C185592680 @default.
• W1992182110 hasConcept C202751555 @default.
• W1992182110 hasConcept C203014093 @default.
• W1992182110 hasConcept C2776042228 @default.
• W1992182110 hasConcept C2777037409 @default.
• W1992182110 hasConcept C2777478134 @default.
• W1992182110 hasConcept C2777983669 @default.
• W1992182110 hasConcept C2778690821 @default.
• W1992182110 hasConcept C2779244956 @default.
• W1992182110 hasConcept C2780007613 @default.
• W1992182110 hasConcept C2781184567 @default.
• W1992182110 hasConcept C28328180 @default.
• W1992182110 hasConcept C55493867 @default.
• W1992182110 hasConcept C86803240 @default.
• W1992182110 hasConcept C95444343 @default.
• W1992182110 hasConceptScore W1992182110C109159458 @default.
• W1992182110 hasConceptScore W1992182110C137061746 @default.
• W1992182110 hasConceptScore W1992182110C153911025 @default.
• W1992182110 hasConceptScore W1992182110C159654299 @default.
• W1992182110 hasConceptScore W1992182110C185592680 @default.
• W1992182110 hasConceptScore W1992182110C202751555 @default.
• W1992182110 hasConceptScore W1992182110C203014093 @default.
• W1992182110 hasConceptScore W1992182110C2776042228 @default.
• W1992182110 hasConceptScore W1992182110C2777037409 @default.
• W1992182110 hasConceptScore W1992182110C2777478134 @default.
• W1992182110 hasConceptScore W1992182110C2777983669 @default.
• W1992182110 hasConceptScore W1992182110C2778690821 @default.
• W1992182110 hasConceptScore W1992182110C2779244956 @default.
• W1992182110 hasConceptScore W1992182110C2780007613 @default.
• W1992182110 hasConceptScore W1992182110C2781184567 @default.
• W1992182110 hasConceptScore W1992182110C28328180 @default.
• W1992182110 hasConceptScore W1992182110C55493867 @default.
• W1992182110 hasConceptScore W1992182110C86803240 @default.
• W1992182110 hasConceptScore W1992182110C95444343 @default.
• W1992182110 hasIssue "1" @default.
• W1992182110 hasLocation W19921821101 @default.
• W1992182110 hasLocation W19921821102 @default.

• next