Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992182272> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1992182272 endingPage "405" @default.
- W1992182272 startingPage "399" @default.
- W1992182272 abstract "Cells of amputated, denervated larval Ambystoma forelimbs dedifferentiate and enter the cell cycle but do not subsequently proliferate sufficiently to form a blastema. The denervated limb stump resorbs slowly until reinnervation stimulates regeneration. We used this system to investigate the fate of cells in denervated limbs which undergo early but limited cycling in response to amputation. In Experiment 1, cells were labeled with [3H]thymidine (3H-T) on Day 4 postamputation (PA)/Day 3 postdenervation (PD). Labeled cells were still present on Day 7 PA, but were less frequently observed on Day 13 PA when the limbs were reinnervated and beginning to regenerate. In Experiment 2 we denervated 1 day preamputation to obtain earlier reinnervation and prevent loss of Day 4 PA labeled cells. Cells labeled with 3H-T on Day 4 PA/Day 5 PD were present throughout the denervation period and most were still present on Day 13 PA. Little or no mitotic activity was found among the labeled cells after the initial round of cycling. The apparent cell cycle block was released upon reinnervation on Days 12 and 13 PA when cycling resumed. Labeled mitotic figures were present on Day 13 PA, and the mitotic index of the labeled population increased as a result of reinnervation. These results demonstrate that blocked cells are rescued by nerves, re-enter the cell cycle, and thus contribute to the reinnervation blastema." @default.
- W1992182272 created "2016-06-24" @default.
- W1992182272 creator A5007736222 @default.
- W1992182272 creator A5078101733 @default.
- W1992182272 creator A5085850696 @default.
- W1992182272 date "1984-12-01" @default.
- W1992182272 modified "2023-10-16" @default.
- W1992182272 title "Rescue of blocked cells by reinnervation in denervated forelimb stumps of larval Ambystoma" @default.
- W1992182272 cites W1554919318 @default.
- W1992182272 cites W1963852894 @default.
- W1992182272 cites W1967423422 @default.
- W1992182272 cites W1969447688 @default.
- W1992182272 cites W1993382065 @default.
- W1992182272 cites W1995137437 @default.
- W1992182272 cites W1998095389 @default.
- W1992182272 cites W2012049029 @default.
- W1992182272 cites W2026935803 @default.
- W1992182272 cites W2030804768 @default.
- W1992182272 cites W2032345813 @default.
- W1992182272 cites W2034843993 @default.
- W1992182272 cites W2044129460 @default.
- W1992182272 cites W2048571053 @default.
- W1992182272 cites W2067746954 @default.
- W1992182272 cites W2071014724 @default.
- W1992182272 cites W2080511128 @default.
- W1992182272 cites W2087007527 @default.
- W1992182272 cites W2088932966 @default.
- W1992182272 cites W2098731389 @default.
- W1992182272 cites W2130208110 @default.
- W1992182272 cites W2155761614 @default.
- W1992182272 cites W2215150572 @default.
- W1992182272 doi "https://doi.org/10.1016/0012-1606(84)90239-2" @default.
- W1992182272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6500181" @default.
- W1992182272 hasPublicationYear "1984" @default.
- W1992182272 type Work @default.
- W1992182272 sameAs 1992182272 @default.
- W1992182272 citedByCount "12" @default.
- W1992182272 countsByYear W19921822722017 @default.
- W1992182272 crossrefType "journal-article" @default.
- W1992182272 hasAuthorship W1992182272A5007736222 @default.
- W1992182272 hasAuthorship W1992182272A5078101733 @default.
- W1992182272 hasAuthorship W1992182272A5085850696 @default.
- W1992182272 hasConcept C105702510 @default.
- W1992182272 hasConcept C171056886 @default.
- W1992182272 hasConcept C2776805190 @default.
- W1992182272 hasConcept C2778646069 @default.
- W1992182272 hasConcept C2779649809 @default.
- W1992182272 hasConcept C2908647359 @default.
- W1992182272 hasConcept C66640590 @default.
- W1992182272 hasConcept C71924100 @default.
- W1992182272 hasConcept C78214289 @default.
- W1992182272 hasConcept C86803240 @default.
- W1992182272 hasConcept C93304396 @default.
- W1992182272 hasConcept C95444343 @default.
- W1992182272 hasConcept C99454951 @default.
- W1992182272 hasConceptScore W1992182272C105702510 @default.
- W1992182272 hasConceptScore W1992182272C171056886 @default.
- W1992182272 hasConceptScore W1992182272C2776805190 @default.
- W1992182272 hasConceptScore W1992182272C2778646069 @default.
- W1992182272 hasConceptScore W1992182272C2779649809 @default.
- W1992182272 hasConceptScore W1992182272C2908647359 @default.
- W1992182272 hasConceptScore W1992182272C66640590 @default.
- W1992182272 hasConceptScore W1992182272C71924100 @default.
- W1992182272 hasConceptScore W1992182272C78214289 @default.
- W1992182272 hasConceptScore W1992182272C86803240 @default.
- W1992182272 hasConceptScore W1992182272C93304396 @default.
- W1992182272 hasConceptScore W1992182272C95444343 @default.
- W1992182272 hasConceptScore W1992182272C99454951 @default.
- W1992182272 hasIssue "2" @default.
- W1992182272 hasLocation W19921822721 @default.
- W1992182272 hasLocation W19921822722 @default.
- W1992182272 hasOpenAccess W1992182272 @default.
- W1992182272 hasPrimaryLocation W19921822721 @default.
- W1992182272 hasRelatedWork W1907506854 @default.
- W1992182272 hasRelatedWork W1989403959 @default.
- W1992182272 hasRelatedWork W1992182272 @default.
- W1992182272 hasRelatedWork W2005729419 @default.
- W1992182272 hasRelatedWork W2017962345 @default.
- W1992182272 hasRelatedWork W2026935803 @default.
- W1992182272 hasRelatedWork W2166999605 @default.
- W1992182272 hasRelatedWork W2274021321 @default.
- W1992182272 hasRelatedWork W2550253619 @default.
- W1992182272 hasRelatedWork W4213137120 @default.
- W1992182272 hasVolume "106" @default.
- W1992182272 isParatext "false" @default.
- W1992182272 isRetracted "false" @default.
- W1992182272 magId "1992182272" @default.
- W1992182272 workType "article" @default.