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- W1992183764 abstract "Notch signaling is a highly conserved mechanism of intercellular communication that controls the developmental fate in all animal species studied to date. Specific transmembrane ligands activate Notch receptors on neighboring cells, thereby inducing proteolytic cleavage and nuclear translocation of the Notch intracellular domain (Notch<sup>IC</sup>). Notch<sup>IC</sup> associates with the transcriptional repressor RBP-J (recombination recognition sequence binding protein at the Jĸ site), also known as CSL [CBF1/Su(H)/Lag-1], and converts it to an activator. In conjunction with chromatin remodeling enzymes, components of the transcriptional machinery and the activity of other cofactors, Notch<sup>IC</sup> induces transcription of downstream target genes, including genes of the Hes (hairy and enhancer of split) and Hey (also called Hes-related repressor Herp, Hesr, Hrt, CHF, gridlock) family. Recent evidence has shown that the Notch pathway is involved in multiple aspects of hematopoietic development. In this review, we summarize the current knowledge of the components and mechanisms of the Notch signaling pathway and discuss the role of Notch in embryonic and adult myelopoiesis. Finally, we will focus on mediators of Notch signaling in the hematopoietic system. We propose that besides suppression of differentiation mediated by the Hes/Hey family, Notch/ RBP-J signaling mediates lineage decisions by direct activation of transcription factors such as PU.1, that are critically involved in directing cells along certain cell lineages, and further influences maturation by activation of functional genes, for example β-globin." @default.
- W1992183764 created "2016-06-24" @default.
- W1992183764 creator A5009784621 @default.
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- W1992183764 creator A5058310204 @default.
- W1992183764 creator A5087322987 @default.
- W1992183764 creator A5087508483 @default.
- W1992183764 date "2008-01-01" @default.
- W1992183764 modified "2023-10-07" @default.
- W1992183764 title "Notch Signaling in Embryonic and Adult Myelopoiesis" @default.
- W1992183764 cites W1553072335 @default.
- W1992183764 cites W1895989020 @default.
- W1992183764 cites W1935396659 @default.
- W1992183764 cites W1965681567 @default.
- W1992183764 cites W1966828612 @default.
- W1992183764 cites W1966834234 @default.
- W1992183764 cites W1968614642 @default.
- W1992183764 cites W1971069863 @default.
- W1992183764 cites W1971368930 @default.
- W1992183764 cites W1974537911 @default.
- W1992183764 cites W1977253322 @default.
- W1992183764 cites W1979755285 @default.
- W1992183764 cites W1980212327 @default.
- W1992183764 cites W1981074229 @default.
- W1992183764 cites W1986357027 @default.
- W1992183764 cites W1989070022 @default.
- W1992183764 cites W1992399976 @default.
- W1992183764 cites W1993517451 @default.
- W1992183764 cites W1994718301 @default.
- W1992183764 cites W1995818612 @default.
- W1992183764 cites W2006013433 @default.
- W1992183764 cites W2007821776 @default.
- W1992183764 cites W2017625115 @default.
- W1992183764 cites W2018339347 @default.
- W1992183764 cites W2019922960 @default.
- W1992183764 cites W2024548275 @default.
- W1992183764 cites W2026827095 @default.
- W1992183764 cites W2028480293 @default.
- W1992183764 cites W2028865293 @default.
- W1992183764 cites W2043279623 @default.
- W1992183764 cites W2044484847 @default.
- W1992183764 cites W2047604499 @default.
- W1992183764 cites W2051433490 @default.
- W1992183764 cites W2055874263 @default.
- W1992183764 cites W2056098053 @default.
- W1992183764 cites W2056916102 @default.
- W1992183764 cites W2058734213 @default.
- W1992183764 cites W2067060241 @default.
- W1992183764 cites W2067131315 @default.
- W1992183764 cites W2067573274 @default.
- W1992183764 cites W2070793750 @default.
- W1992183764 cites W2072884392 @default.
- W1992183764 cites W2074072596 @default.
- W1992183764 cites W2075947758 @default.
- W1992183764 cites W2081807421 @default.
- W1992183764 cites W2085021251 @default.
- W1992183764 cites W2086677653 @default.
- W1992183764 cites W2087871321 @default.
- W1992183764 cites W2088725431 @default.
- W1992183764 cites W2089306515 @default.
- W1992183764 cites W2090883050 @default.
- W1992183764 cites W2091096050 @default.
- W1992183764 cites W2093577257 @default.
- W1992183764 cites W2093983301 @default.
- W1992183764 cites W2096275446 @default.
- W1992183764 cites W2098722719 @default.
- W1992183764 cites W2100946822 @default.
- W1992183764 cites W2107439277 @default.
- W1992183764 cites W2109380828 @default.
- W1992183764 cites W2110521270 @default.
- W1992183764 cites W2114637736 @default.
- W1992183764 cites W2115181518 @default.
- W1992183764 cites W2118453722 @default.
- W1992183764 cites W2118644071 @default.
- W1992183764 cites W2121878535 @default.
- W1992183764 cites W2128295200 @default.
- W1992183764 cites W2132198622 @default.
- W1992183764 cites W2141081519 @default.
- W1992183764 cites W2149557024 @default.
- W1992183764 cites W2150792687 @default.
- W1992183764 cites W2152244674 @default.
- W1992183764 cites W2153360321 @default.
- W1992183764 cites W2154861644 @default.
- W1992183764 cites W2155276021 @default.
- W1992183764 cites W2161234257 @default.
- W1992183764 cites W2169281107 @default.
- W1992183764 cites W2301310480 @default.
- W1992183764 cites W2314219042 @default.
- W1992183764 cites W2329147463 @default.
- W1992183764 cites W2333937140 @default.
- W1992183764 cites W275773222 @default.
- W1992183764 cites W4213058179 @default.
- W1992183764 cites W4236113312 @default.
- W1992183764 cites W4254651173 @default.
- W1992183764 cites W45534775 @default.
- W1992183764 cites W82909710 @default.